Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis

Zhang, Ni; Zhang, Hui; Law, Betty Yuen Kwan; Dias, Ivo Ricardo de Seabra Rodrigues; Qiu, Cong; Zeng, Wu; Pan, Hu Dan; Chen, Jin Yun; Bai, Yan; Lv, Jing; Li, Qu; Chen, Xi; Huang, Qi; Zhang, Wei; Li, Yang; Yu, Lu; Han, Yu; Huang, Guo Xin; Wang, Hui Miao; Sun, Xiaolei; Zhang, Yun; He, Haonan; Luo, Wei; Xiao, Yao; Zhou, Jian; Xu, Ting; Huang, Qing; Wu, Min; Huang, Zhi Sheng; Liu, Wei; Wong, Vincent Kam Wai; Liu, Liang

doi:10.1038/s41423-020-0380-4

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…Spleen and thymus are crucial organs in the mammalian immune system, and their relative organ weight is an important index for measuring immune function [17] . As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Chen

Zhang

Zeng

et al. 2022

Journal of Advanced Research

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“…Spleen and thymus are crucial organs in the mammalian immune system, and their relative organ weight is an important index for measuring immune function [17] . As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Chen

Zhang

Zeng

et al. 2022

Journal of Advanced Research

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“…In addition, SIRT5 can deacetylate the mitochondrial intermembrane space (IMS) cytochrome c protein in vitro, which is involved in oxidative metabolism and apoptosis [ 56 ]. Studies have shown that SIRT5 mRNA expression is significantly reduced in RA patients compared to healthy subjects [ 24 ]. In addition, SIRT5 has been shown to regulate chondrocyte metabolism, including amino acid metabolism, the tricarboxylic amide cycle, and glycolysis [ 57 ].…”

Section: Sirtuins Familymentioning

confidence: 99%

“…It was also shown that blocking SIRT5 significantly enhances the release of TNF-α and IL-1β, which are involved in the development of RA. SIRT5 deficiency increased the severity of this disease [ 24 ].…”

Section: Sirtuins Familymentioning

confidence: 99%

Role of Sirtuins in the Pathogenesis of Rheumatoid Arthritis

Poniewierska-Baran

Bochniak

Warias

et al. 2023

IJMS

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Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease leading to joint destruction. The causes of RA are not fully known. Most likely, the development of the disease depends on the coexistence of many factors, such as hereditary factors, immune system defects, gender, infectious agents, nicotine, and stress. Various epigenetic changes have been identified and correlated with the aggressive phenotype of RA, including the involvement of sirtuins, which are enzymes found in all living organisms. Their high content in the human body can slow down the aging processes, reduce cell death, counteract the appearance of inflammation, and regulate metabolic processes. Sirtuins can participate in several steps of RA pathogenesis. This narrative review presents, collects, and discusses the role of all sirtuins (1–7) in the pathogenesis of rheumatoid arthritis.

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“…SIRT4 gene plays an important role in maintaining the mitochondrial redox state (52), and its high expression promotes TNF-a and IL-6 secretion and accelerates the process of bone destruction in patients with osteoarthritis (52,53). SIRT5 gene expression is downregulated in the macrophage activation zone, and knockdown of SIRT5 in model rats significantly enhances the release of TNF-a and IL-1β, mediating the development of RA (54). Whereas, SIRT5 reprograms the metabolic process of macrophages to inhibit pro-inflammation by activating PKM2 kinase activity and blocking IL-1β production in macrophages (55).…”

Section: Figurementioning

confidence: 99%

Rheumatoid arthritis and mitochondrial homeostasis: The crossroads of metabolism and immunity

et al. 2022

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Rheumatoid arthritis is an autoimmune disease characterized by chronic symmetric synovial inflammation and erosive bone destruction. Mitochondria are the main site of cellular energy supply and play a key role in the process of energy metabolism. They possess certain self-regulatory and repair capabilities. Mitochondria maintain relative stability in number, morphology, and spatial structure through biological processes, such as biogenesis, fission, fusion, and autophagy, which are collectively called mitochondrial homeostasis. An imbalance in the mitochondrial homeostatic environment will affect immune cell energy metabolism, synovial cell proliferation, apoptosis, and inflammatory signaling. These biological processes are involved in the onset and development of rheumatoid arthritis. In this review, we found that in rheumatoid arthritis, abnormal mitochondrial homeostasis can mediate various immune cell metabolic disorders, and the reprogramming of immune cell metabolism is closely related to their inflammatory activation. In turn, mitochondrial damage and homeostatic imbalance can lead to mtDNA leakage and increased mtROS production. mtDNA and mtROS are active substances mediating multiple inflammatory pathways. Several rheumatoid arthritis therapeutic agents regulate mitochondrial homeostasis and repair mitochondrial damage. Therefore, modulation of mitochondrial homeostasis would be one of the most attractive targets for the treatment of rheumatoid arthritis.

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Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis

Cited by 12 publications

References 10 publications

Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Role of Sirtuins in the Pathogenesis of Rheumatoid Arthritis

Rheumatoid arthritis and mitochondrial homeostasis: The crossroads of metabolism and immunity

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