Role of Sirtuins in the Pathogenesis of Rheumatoid Arthritis

Poniewierska-Baran, Agata; Bochniak, Oliwia; Warias, Paulina; Pawlik, Andrzej

doi:10.3390/ijms24021532

Cited by 5 publications

(3 citation statements)

References 89 publications

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“…On these bases, SIRTs act as "cellular sensors" since, in response to stress phenomena caused by metabolic deficits or oxidative damage, they counteract aging by contributing to cell survival [14] (Figure 2). Consistent with this, changes in SIRT expression and activity are associated with pathological conditions, ranging from insulin resistance and type 2 diabetes (T2D) [15], to oxidative stress and kidney damage [16], cardiovascular and gynecological diseases [2,17,18], rheumatoid arthritis [19], neuro-inflammation [20,21], and various types of cancer [22][23][24]. In this light, a regulation of SIRT activity might support the treatment of the above-mentioned diseases.…”

Section: Introductionmentioning

confidence: 61%

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Lombardo,

Russo,

Maugeri

et al. 2024

IJMS

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Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent class III histone deacetylases, which come into play in the regulation of epigenetic processes through the deacetylation of histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), which are localized into the nucleus, cytoplasm, and mitochondria, with different enzymatic activities and regulatory mechanisms. Indeed, SIRTs are involved in different physio-pathological processes responsible for the onset of several human illnesses, such as cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer. Nowadays, it is well-known that Citrus fruits, typical of the Mediterranean diet, are an important source of bioactive compounds, such as polyphenols. Among these, flavonoids are recognized as potential agents endowed with a wide range of beneficial properties, including antioxidant, anti-inflammatory, hypolipidemic, and antitumoral ones. On these bases, we offer a comprehensive overview on biological effects exerted by Citrus flavonoids via targeting SIRTs, which acted as modulator of several signaling pathways. According to the reported studies, Citrus flavonoids appear to be promising SIRT modulators in many different pathologies, a role which might be potentially evaluated in future therapies, along with encouraging the study of those SIRT members which still lack proper evidence on their support.

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Section: Introductionmentioning

confidence: 61%

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Lombardo,

Russo,

Maugeri

et al. 2024

IJMS

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“…For example, Sirt1, Sirt2, Sirt3, Sirt5, Sirt6, and Sirt7 all have NAD + -dependent deacetylase activity that mediates the deacetylation of histones and non-histones. Sirt4 [ 19 ] and Sirt6 have mono-ADP-ribosyltransferase activity [ 20 ], and Sirt5 is also a desuccinylase [ 21 ]. Sirtuins require NAD + as a catalytic cofactor and can hence be inhibited by NADH; therefore, sirtuins are particularly sensitive to the intracellular NAD + /NADH ratios [ 22 ].…”

Section: The Origin and Function Of The Sirtuin Familymentioning

confidence: 99%

Sirtuins in kidney diseases: potential mechanism and therapeutic targets

Jin,

Ma,

Liu

et al. 2024

Cell Commun Signal

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Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various biological processes, including DNA damage repair, immune inflammation, oxidative stress, mitochondrial homeostasis, autophagy, and apoptosis. Sirtuins are essential regulators of cellular function and organismal health. Increasing evidence suggests that the development of age-related diseases, including kidney diseases, is associated with aberrant expression of sirtuins, and that regulation of sirtuins expression and activity can effectively improve kidney function and delay the progression of kidney disease. In this review, we summarise current studies highlighting the role of sirtuins in renal diseases. First, we discuss sirtuin family members and their main mechanisms of action. We then outline the possible roles of sirtuins in various cell types in kidney diseases. Finally, we summarise the compounds that activate or inhibit sirtuin activity and that consequently ameliorate renal diseases. In conclusion, targeted modulation of sirtuins is a potential therapeutic strategy for kidney diseases.

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“…Moreover, the authors report the current knowledge of the use of phage display peptides as a promising tool in osteochondral repair strategies. Furthermore, the involvement of sirtuins, enzymes involved in the cell metabolism and the regulation of several cellular functions, has been discussed in relation to the pathophysiology of RA by Pniewierska-Baran et al [ 27 ]. The authors suggest that the activation of these small molecules is able to limit the development of autoimmune and inflammatory diseases such as RA by promoting cell survival pathways and attenuating the inflammatory process.…”

mentioning

confidence: 99%