Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Chen, Xi; Zhang, Hui; Zeng, Wu; Wang, Nick; Lo, Hang Hong; Ip, Chi Kio; Li, Yang; Hsiao, W.L. Wendy; Sin, Wai Man; Xia, Chenglai; Law, Betty Yuen Kwan; Wong, Vincent Kam Wai

doi:10.1016/j.jare.2021.08.015

Cited by 12 publications

(5 citation statements)

References 52 publications

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“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that the upregulated expressed genes were enriched in IL-17, TNF, toll-like receptor, and other signaling pathways (Additional file 1 : Fig. S1D) involved in inflammatory response and autoimmunity [ 23 ]. GO and KEGG analyses of the downregulated expressed genes showed that they were mainly enriched in muscle contraction, PPAR signaling and inflammatory mediator regulation of TRP channels (Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

et al. 2022

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Background Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present study, we aim to investigate the effect of IUI on lung development, and to identify the key molecule involved in this process and its epigenetic regulatory mechanism. Results Serpine1 was upregulated in the lung tissue of neonatal mice with IUI. Intranasal delivery of Serpine1 siRNA markedly reversed IUI-induced lung injury. Serpine1 overexpression substantially promoted cell senescence of both human and murine lung epithelial cells, reflected by decreased cell proliferation and increased senescence-associated β-galactosidase activity, G0/G1 cell fraction, senescence marker, and oxidative and DNA damage marker expression. IUI decreased the methylation level of the Serpine1 promoter, and methylation of the promoter led to transcriptional repression of Serpine1. Furthermore, IUI promoted the expression of Tet1 potentially through TNF-α, while Tet1 facilitated the demethylation of Serpine1 promoter. DNA pull-down and ChIP assays revealed that the Serpine1 promoter was regulated by Rela and Hdac2. DNA demethylation increased the recruitment of Rela to the Serpine1 promoter and induced the release of Hdac2. Conclusion Increased Serpine1 expression mediated by DNA demethylation causes lung injury in neonatal mice with IUI. Therefore, therapeutic interventions targeting Serpine1 may effectively prevent IUI-induced lung injury.

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Section: Resultsmentioning

confidence: 99%

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

et al. 2022

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“…Then the AIA was induced in rats by the subcutaneous injection of a suspension agent (100 μL) at the base of the tail and on day 9 the symptoms of arthritis began to develop gradually. 44…”

Section: Methodsmentioning

confidence: 99%

Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

Meng,

Song,

Tang

et al. 2023

Biomater. Sci.

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“…Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease, with main pathological features including synovitis, synovial tissue hyperplasia and cartilage destruction [1]. RA has become a serious public health problem, with a global incidence of 0.6%-1% and an incidence of about 0.4% in China [2]. Fibroblast-like synoviocytes (FLS) play a crucial role in the perpetuation of RA, and the abnormal activation of FLS are key effector cells in synovitis [3].…”

Section: Introductionmentioning

confidence: 99%

The HIF-1/ BNIP3 pathway mediates mitophagy to inhibit the pyroptosis of fibroblast-like synoviocytes in rheumatoid arthritis

Hong,

Wang,

Zhang

et al. 2024

International Immunopharmacology

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Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Cited by 12 publications

References 52 publications

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

The HIF-1/ BNIP3 pathway mediates mitophagy to inhibit the pyroptosis of fibroblast-like synoviocytes in rheumatoid arthritis

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