Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

Meng, Shiyu; Song, Zhiling; Tang, Zhuang; Yang, Xiaoxue; Xiao, Yi; Guo, Hui; Zhou, Kaixiang; Du, Meirong; Zhu, Yi Zhun; Wang, Xiaolin

doi:10.1039/d3bm00911d

Biomater. Sci.

2023

DOI: 10.1039/d3bm00911d

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Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

Shiyu Meng,

Zhiling Song,

Zhuang Tang

et al.

Abstract: Construction of HAP-1 peptide-engineered liposomal leonurine (HAP-Lipo@Leo) for efficient treatment of rheumatoid arthritis by downregulating inflammation, halting migration and invasion of activated FLS, and preserving cartilage/bone integrity.

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2024

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Cited by 3 publications

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Bioengineered Silk Protein‐Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications

Shuai,

Zheng,

Kundu

et al. 2024

Adv Healthcare Materials

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Abstract3D in vitro model has emerged as a valuable tool for studying tissue development, drug screening, and disease modeling. 3D systems can accurately replicate tissue microstructures and physiological features, mirroring the in vivo microenvironment departing from conventional 2D cell cultures. Various 3D in vitro models utilizing biomacromolecules like collagen and synthetic polymers have been developed to meet diverse research needs and address the complex challenges of contemporary research. Silk proteins, bearing structural and functional similarities to collagen, have been increasingly employed to construct advanced 3D in vitro systems, surpassing the limitations of 2D cultures. This review examines silk proteins' composition, structure, properties, and functions, elucidating their role in 3D in vitro models. Furthermore, recent advances in biomedical applications involving silk‐based organoid models are discussed. In particular, the unique physiological attributes of silk matrix constituents in in vitro tissue constructs are highlighted, providing a meticulous evaluation of their importance. Additionally, it outlines the current research hurdles and complexities while contemplating future avenues, thereby paving the way for developing complex and biomimetic silk protein‐based microtissues.

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Bioengineered Silk Protein‐Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications

Shuai,

Zheng,

Kundu

et al. 2024

Adv Healthcare Materials

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Nanoformulation-assisted microneedle transdermal drug delivery system: An innovative platform enhancing rheumatoid arthritis treatment

Wendong,

Xingxing,

Xianze

et al. 2024

Biomedicine & Pharmacotherapy

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Cell membrane camouflaged and ROS responsive nanosomes for targeted endometriosis therapy via reversing inflammatory, low-autophagy, and immunotolerant microenvironment

Tang,

Zhang,

Meng

et al. 2024

Chemical Engineering Journal

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Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

Abstract: Construction of HAP-1 peptide-engineered liposomal leonurine (HAP-Lipo@Leo) for efficient treatment of rheumatoid arthritis by downregulating inflammation, halting migration and invasion of activated FLS, and preserving cartilage/bone integrity.

Cited by 3 publications

References 47 publications

Bioengineered Silk Protein‐Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications

Bioengineered Silk Protein‐Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications

Nanoformulation-assisted microneedle transdermal drug delivery system: An innovative platform enhancing rheumatoid arthritis treatment

Cell membrane camouflaged and ROS responsive nanosomes for targeted endometriosis therapy via reversing inflammatory, low-autophagy, and immunotolerant microenvironment

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