Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

Łukawska-Tatarczuk, Magdalena; Franek, Edward; Czupryniak, Leszek; Joniec-Maciejak, Ilona; Pawlak, Agnieszka; Wojnar, Ewa; Zieliński, Jakub; Mirowska‐Guzel, Dagmara; Mrozikiewicz-Rakowska, Beata

doi:10.3390/biom11081110

Cited by 12 publications

(13 citation statements)

References 93 publications

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“…Thyroid autoimmunity is possibly associated with activation of the pathways that promote atherosclerosis, which may contribute to the loss of vasoprotection in women, explaining why they are at higher cardiovascular risk. Own elaboration based on the data obtained in the study and [5,6,8,21,22,29,31,38,41]. Th -T helper cell; HT -Hashimoto's thyroiditis; aTPO -anti-thyroid peroxidase antibody; fT3 -free triiodothyronine…”

Section: Discussionmentioning

confidence: 99%

“…What is important, these factors associated with autoimmunity are also important in regulating the inflammatory processes that underlie CV complication [40]. Interestingly, epigenetic factors may mediate the link between autoimmunity, adipose tissue, and the atherosclerotic plaque formation [41], but the exact mechanism of these relationships remains unclear and requires further study. Figure 2 shows the possible mechanisms involved in the association between factors related to thyroid autoimmunity and atherosclerosis in women.…”

Section: Original Papermentioning

confidence: 99%

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Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Łukawska-Tatarczuk

Zieliński²,

Franek

et al. 2022

Endokrynol Pol

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opment of diabetic complications, of which the most significant association is suspected in CV complication in T1DM [3]. It seems that an imbalance in the immune system may be a key trigger of processes underlying atherosclerosis, which include inflammation [4], endothelial dysfunction [5], and accumulation of prothrombotic factors [6]. Interestingly, autoimmune factors in CV complications appear to be particularly relevant in women. It was found that the antioxidant and anti-inflammatory effects of oestrogen observed in healthy women are due to the regulatory Th2, macrophage, and T regulatory cell immune response and are probably disrupted in the presence of autoimmune Endokrynologia Polska

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Section: Discussionmentioning

confidence: 99%

Section: Original Papermentioning

confidence: 99%

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Łukawska-Tatarczuk

Zieliński²,

Franek

et al. 2022

Endokrynol Pol

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“…The possible mechanisms associated with this relationship are the activation of the inflammatory process and oxidative stress connected with thyroid autoimmunity, which may have a systemic effect [34][35][36]. Indeed, it has recently been shown that early myocardial dysfunction may be related to sirtuin 1 and interleukin 27, the serum concentrations of which were higher in women with T1DM and HT than in women with T1DM alone and correlated significantly with several echocardiographic parameters [37]. This is a new insight into the development of HF in women with T1DM and needs to be verified in further research.…”

Section: Original Papermentioning

confidence: 99%

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle‑tracking echocardiography

et al. 2022

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Introduction:The presence of diabetes is associated with loss of cardioprotection in premenopausal women; however, the mechanisms involved remain unknown. Autoimmune factors are suspected to play a role in cardiovascular complications, especially in type 1 diabetes (T1DM). The aim of this pilot study was to explore whether antithyroid peroxidase antibody (aTPO) as a marker of increased immune activity is related to cardiac dysfunction in young, asymptomatic women with T1DM. Material and methods: Eighty-eight euthyroid women (59 with T1DM and 29 healthy controls) underwent physical examination, laboratory tests, thyroid ultrasound, and two-dimensional speckle-tracking echocardiography. According to the antiperoxidase antibodies (aTPO) titre, the T1DM women were divided into an aTPO positive (T1DM aTPO+) (n = 34) and an aTPO negative (T1DM aTPO-) (n = 25) group. The relationship between thyroid autoimmunity parameters and echocardiographic parameters was evaluated. Results: Global longitudinal strain (GLS) was slightly reduced in the T1DM aTPO+ group compared to T1DM aTPO-and significantly compared to controls (p = 0.051 and p = 0.015, respectively). Although, the lower values of longitudinal strain of left ventricular were found in the majority of segments in the T1DM aTPO+ group in comparison to T1DM aTPO-and controls, significant differences were only found in the two-chamber view (specifically in the anterior segments) between the T1DM aTPO+ and T1DM aTPO-groups (p = 0.030) and in the four-chamber view (specifically in the anterolateral segments) between the T1DM aTPO+ group and controls (p = 0.021). Echocardiographic parameters of diastolic and systolic function of both ventricles were significantly correlated with parameters of thyroid autoimmunity. A logistic regression analysis showed that Hashimoto's thyroiditis (HT) duration [odds ratio (OR): 0.997, 95% confidence interval (CI): 0.995-0.999, p = 0.008), the dose of levothyroxine (OR: 0.814, 95% CI: 0.689-0.960, p = 0.013), and reduced echogenicity on thyroid ultrasound (OR: 0.309, 95% CI: 0.120-0.793, p = 0.013) had a significant influence on reduced GLS. Conclusions: Our results suggest that coexistence of aTPO with T1DM was associated with poorer myocardial function, particularly in the anterior and anterolateral segments, which may be related to an autoimmune factor. The impaired function of these segments is probably the first sign of myocardial systolic dysfunction in women with T1DM, which needs to be confirmed in further studies.

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“…There have been preclinical and clinical studies indicating the significance of SIRT1 in the pathogenesis of Ads, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), multiple sclerosis (MS), etc. In women Hashimoto's disease patients with type 1 diabetes mellitus, SIRT1 contributed to the pathogenesis of early cardiac dysfunction (10). Agathe et al performed microarray experiments to identify SIRT1 as a relevant gene candidate associated with pathological angiogenesis in autoimmune arthritis mice (11).…”

Section: Introductionmentioning

confidence: 99%

SIRT1: A Potential Therapeutic Target in Autoimmune Diseases

Shen

Deng²,

Chen³

et al. 2021

Front. Immunol.

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The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, and the identification of novel therapeutic strategies for prevention and treatment is urgently needed. Sirtuin 1 (SIRT1), a member of the class III family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, has been reported to participate in the progression of several diseases. SIRT1 also regulates inflammation, oxidative stress, mitochondrial function, immune responses, cellular differentiation, proliferation and metabolism, and its altered functions are likely involved in Ads. Several inhibitors and activators have been shown to affect the development of Ads. SIRT1 may represent a novel therapeutic target in these diseases, and small molecules or natural products that modulate the functions of SIRT1 are potential therapeutic agents. In the present review, we summarize current studies of the biological functions of SIRT1 and its role in the pathogenesis and treatment of Ads.

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Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

Cited by 12 publications

References 93 publications

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle‑tracking echocardiography

SIRT1: A Potential Therapeutic Target in Autoimmune Diseases

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