Sintering behaviour of carbonated hydroxyapatite prepared at different carbonate and phosphate ratios

Safarzadeh, Marjan; Ramesh, S.; Tan, C.Y.; Chandran, Hari; Ching, Yern Chee; Noor, Ahmad Fauzi Mohd; Krishnasamy, Sivakumar; Teng, W.D.

doi:10.1016/j.bsecv.2019.08.001

Cited by 32 publications

(11 citation statements)

References 51 publications

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“…No peak was detected at 867 cm -1 confirming the prepared samples was free of HPO4 - [24]. Furthermore, no bands were detected at 871-873 cm -1 and 1416-1486 cm -1 , indicating the entire materials were free of carbonate groups [28]. With addition of SO4 2ions, neglected shifted was observed in the wavelength of the functional groups and a clear reduction in peaks sharpness was observed, more obvious for PO4 3-groups which could be indicate to a reduction in degree of crystallinity as mentioned in the XRD paragraph (Table 2).…”

Section: Resultsmentioning

confidence: 88%

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Structural and Morphological Analysis of Nano Sized Anions Doped Hydroxyapatite

2021

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Inorganic sulphate and silicate is required by all mammalian cells to function properly, it is the most abundant anion in the human plasma. Sulphate ions are the major source of sulphur which is considered an important element for sustenance of life as it is present in the essential amino and is required by cells to function properly.This paper aimed to compare the constitutional and physical property of pure hydroxyapatite (HA) doped with different kinds of anions such as sulphate ions (SO4 2-) and silicate ions (SiO4 4-). The pure phase of HA, SHA (SO4 2doped HA), and SiHA (SiO4 4doped HA) were successfully synthesised using microwave-assisted precipitation technique method. The acquired materials were recognized using X-ray diffractometer (XRD), Fourier transforms infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and energydispersive X-ray (EDX) techniques. The consequence shows that incorporation of SO4 2and SiO4 4ions revealed shrinkage along with a-axis and expansion with c-axis. FTIR shows diminished in the intensity of the OH group with an addition of anions. The particles shape significantly decreased with incorporation of SiO4 4ions and changed to rod shape with addition of SO4 2-. The Ca/P ratios were in acceptable values. Based on the outcomes, demonstrated that the anions were successfully integrated in the HA crystal with no decomposition in HA phase.

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Section: Resultsmentioning

confidence: 88%

“…However, the obtained results were in a good match with previous studies. Safarzadeh et al used a wet chemical method to synthesis pure phase of HA and the shape of particles appeared in spheroid shape [28]. With incorporation of SO4 2ions, the shape of the particles was completely changed to needle shape, as approved by previous analysis [29].…”

Section: Resultsmentioning

confidence: 98%

Structural and Morphological Analysis of Nano Sized Anions Doped Hydroxyapatite

2021

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“…at 2 θ = 26°, corresponded to (002), three overlapping peaks at 2 θ = 32° to 34° which represents (211), (300) and (202), 2 θ = 40° indexed to (310), 2 θ = 47° to 53° indexed to (222), (213) and (004), respectively. 16 It is noticed that the incorporation of CO 3 2into apatite structure had slightly altered the crystal lattice resulting in the contraction of a-axis and extension of c-axis relative to the standard reference of pure HA (a = 9.418 Å, c = 6.884 Å), indicating the formation of B-type CHA for all CHA produced powders. 17,18 By comparing the XRD pattern of as-synthesised CHA powders produced, it was observed that the peaks slightly shifted to lower angle (2 θ), particularly between 25° < (2 θ) < 35° with increasing of CO 3 2addition during synthesis.…”

Section: Resultsmentioning

confidence: 93%

Effect of Carbonate to Phosphate Molar Ratios on the Physico-Chemical Properties of Carbonated Hydroxyapatite Nanopowder

Noor

Afandi

Noor

et al. 2020

JES

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The aim of this study was to incorporate carbonate ions (CO3 2–) into the hydroxyapatite (HA) crystal structure followed by investigation on the effect of different carbonate to phosphate (CO3 2–/PO4 3–) ratios on the phase purity, crystal structure as well as CO3 2– content present in the apatite structure. CO3 2– substitution has been proposed to enhance the performance of HA-based material, particularly on the physico-chemical properties. Three different compositions of carbonated hydroxyapatite (CHA) powder with different CO3 2–/ PO4 3– ratios (namely, CHA 1:1, CHA 2:1 and CHA 4:1) were chemically synthesised by nanoemulsion method at 37°C and characterised for their physico-chemical properties. Results demonstrated that all as-synthesised powders formed single phase B-type CHA without any additional phases. Interestingly, an increasing amount of CO3 2– substituted into the apatite structure gives rise to the formation of CHA structure with a variation on their cell parameters and the degree of crystallinity. An increase in the CO3 2–/ PO4 3– ratio was also found to lead a higher amount of CO3 2– content present in the as-synthesised powder (in a range of 4 wt % to 10 wt %), which is comparable to the CO3 2– content found in the human bone mineral.

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“…2). Despite the loss of carbonate during sintering, the amount remained in all sintered scaffolds still fall in the range of carbonate presents in native human bone (2-8 wt%) [29], [35].…”

Section: Scaffold Characterizationmentioning

confidence: 92%

Influence of ternary divalent cations (Mg2+, Co2+, Sr2+) substitution on the physicochemical, mechanical and biological properties of carbonated hydroxyapatite scaffolds

B.I.

M.N.

et al. 2021

J Aust Ceram Soc

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Substitution of ionic either anion or cation in a controlled amount into carbonated hydroxyapatite (CHA) structure is one of the efficient and safest ways in enhancing the properties of the materials. However, most of the works studied only focused on the physical and mechanical properties of single ionic substitution. For the first time, the influence of simultaneous ternary substitutions of divalent cations into porous CHA scaffolds on the physicochemical, mechanical, degradation and in vitro biological properties are investigated in the present study. Three different compositions of porous scaffolds with binary and ternary divalent cations, namely, pure CHA (S11), CoSr CHA (S21) and MgCoSr CHA (S31) were fabricated using polyurethane (PU) foam replication technique. Despite a small amount of Mg 2+ , Co 2+ and Sr 2+ added, these divalent cations had successfully substituted into the Ca 2+ site and remained as single phase B-type CHA. The produced scaffolds demonstrated open, interconnected and uniform pores. Interestingly, simultaneous ternary divalent cations substitution into CHA structure had successfully enhanced the compressive strength of the sintered scaffolds, also promoted better cell attachment and activities than the binary dopedand pure CHA scaffolds. It is important to note that the right choice of divalent cation can be the determining factor in tuning the physicochemical, mechanical and biological properties of CHA scaffolds.

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Sintering behaviour of carbonated hydroxyapatite prepared at different carbonate and phosphate ratios

Cited by 32 publications

References 51 publications

Structural and Morphological Analysis of Nano Sized Anions Doped Hydroxyapatite

Structural and Morphological Analysis of Nano Sized Anions Doped Hydroxyapatite

Effect of Carbonate to Phosphate Molar Ratios on the Physico-Chemical Properties of Carbonated Hydroxyapatite Nanopowder

Influence of ternary divalent cations (Mg2+, Co2+, Sr2+) substitution on the physicochemical, mechanical and biological properties of carbonated hydroxyapatite scaffolds

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