Sinonasal inverted papilloma: A case report and mini review of histopathological features

Khandekar, Shubhangi; Dive, Alka; Mishra, Rakesh; Upadhyaya, Neha

doi:10.4103/0973-029x.174644

Cited by 22 publications

(16 citation statements)

References 22 publications

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“…Typically, the schneiderian papillomas are unilateral, bilateral papillomas may also occur. 2 Inverted papillomas are generally diagnosed at a late stage,1-4 years after first onset of sinonasal symptoms. Functional signs and symptoms are nonspecific and vary according to the site of occurrence; they include nasal obstruction, anterior and/or posterior rhinorrhea, epistaxis, hyposmia or anosmia, symptomatic mass or facial pain.…”

Section: Discussionmentioning

confidence: 99%

“…The basal membrane is intact. 2 Radiological assessment done with CT scan and MRI scan being the most common. Sinus CT is systematic.…”

Section: Discussionmentioning

confidence: 99%

“…4 Tumor recurrence usually occur in the first two years, but in some cases it occurs after 6 years of evolution so patient follow up for at least 6 years should be done. 2…”

Section: Discussionmentioning

confidence: 99%

“…1 In 1854, Ward first described the inverted papilloma in the sinonasal cavity. 2 Inverted papilloma arises from lateral wall of nasal cavity and it secondarily involves the maxillary, ethmoidal, frontal and sphenoidal sinuses. It is extremely rare for paranasal sinuses to be primarily involved, occurring only in 5% of the cases.…”

Section: Introductionmentioning

confidence: 99%

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Inverted Papilloma: A Case Report

Riaz¹,

Saeed²,

Yasmin³

2020

J Pak Dent Assoc

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Section: Discussionmentioning

confidence: 99%

“…The basal membrane is intact. 2 Radiological assessment done with CT scan and MRI scan being the most common. Sinus CT is systematic.…”

Section: Discussionmentioning

confidence: 99%

“…4 Tumor recurrence usually occur in the first two years, but in some cases it occurs after 6 years of evolution so patient follow up for at least 6 years should be done. 2…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inverted Papilloma: A Case Report

Riaz¹,

Saeed²,

Yasmin³

2020

J Pak Dent Assoc

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“…1 It comprises 0.5-4% of all primary nasal tumors. 2,3 and is more common in males around a 5-6th decade. It is a rare benign tumor with the tendency to recur and even malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Schneiderian (sinonasal) papilloma: An uncommon rare entity

Barman¹,

Priyadharisini²

2021

ACHR

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Sinonasal papilloma is a benign surface mucosal neoplasm with variable growth pattern and cytological features. It is a rare benign tumor with tendency to recur and also malignant transformation. The most common sites of inverting papillomata are lateral nasal wall and middle meatus and are usually unilateral. Rarely Bilateral disease can occur, which may be due to direct extension of the tumour, but can also occur as two distinct lesions. The etiology still remains unclear, eventhough the morphology and clinical behavior of this lesion has been well described. Here we report a case of recurrent bilateral nasal polyposis, histologically diagnosed as Inverted sinonasal papilloma, which is a rare entity.

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The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review

Gupta

Rády

Sikora

et al. 2020

Reviews in Medical Virology

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Sinonasal inverted papillomas (IPs) are rare tumours arising from the nasal epithelial mucosa. Most lesions are benign, but a subset of IPs progress to dysplasia and squamous cell carcinoma. Although the epidemiology and clinical features of IPs are well known, the pathogenesis is still unclear. Given the established role of human papillomaviruses (HPVs) in the formation of other mucosal tumours including cervical and oropharyngeal cancer, some have suggested the virus may play a role in IP development. However, the association between HPV and IPs has not yet been proven, and the variable detection of HPV DNA in IPs has cast uncertainty on whether the virus plays a major role in pathogenesis. In this review, we summarize early clinical reports and synthesize recent studies that may elucidate the association between HPV and IPs. We also discuss the role HPV may have in the progression of benign IP to dysplasia and malignancy, as well as potential pathological mechanisms. We hope that synthesizing the initial and recent studies on this topic will not only lead to a better understanding of research in the role of HPV in IP development, but also help guide and contextualize future studies. K E Y W O R D SHPV, inverted papilloma, review, sinonasal papilloma, virology | INTRODUCTIONInverted papilloma (IP) is a rare benign epithelial tumour of the sinonasal tract. 1 The annual incidence rate of IP is approximately 0.6 cases per 100,000 people, and it comprises between 0.5% and 4% of all primary nasal tumours. 2 Despite its overall rarity, IP is the most common form of sinonasal papilloma. 1 IPs tend to occur more commonly in males, with a ratio between two and five males to one female. 1 The mean age at presentation is roughly 55 years. 3 The diagnosis is usually made via nasal endoscopy showing a red-grey exophytic, polypoidal, and vascular lesion typically arising from the lateral nasal wall. 2 Despite being benign, IPs have a high rate of recurrence and are known for local aggressiveness. 4,5 Progression to synchronous or metachronous squamous cell carcinoma (SCC) is a hallmark of these lesions, with occurrence ranging from 2% to 27% of IPs. 6 The lesions are typically diagnosed by otolaryngologists and head and neck cancer specialists; however, patients with IPs may present to a variety of specialists. 2,7 IPs typically present with unilateral nasal obstruction, rhinorrhoea, epistaxis or sinusitis with nasal discharge. 2 While the epidemiology and clinical features of IP have been well characterized, the aetiology and risk factors remain controversial.Infection with human papillomavirus (HPV) is one such debated risk factor that has been posited to play a role in the pathogenesis of IP.Abbreviations: DIP, dysplastic inverted papilloma; EGFR, epidermal growth factor receptor; HPV, human papillomavirus; IP, inverted papilloma; ISH, in situ hybridization; MIP, malignant inverted papilloma; NMIP, non-malignant inverted papilloma; PCR, polymerase chain reaction; RT-PCR, reverse transcription polymerase chain reaction; SC...

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Sinonasal inverted papilloma: A case report and mini review of histopathological features

Cited by 22 publications

References 22 publications

Inverted Papilloma: A Case Report

Inverted Papilloma: A Case Report

Bilateral Schneiderian (sinonasal) papilloma: An uncommon rare entity

The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review

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