Sinonasal Clear Cell Adenocarcinoma

Negahban, Shahrzad; Daneshbod, Yahya; Khademi, Bijan; Rasekhi, Alireza; Soleimanpour, Hossein

doi:10.1159/000325393

Cited by 9 publications

(4 citation statements)

References 4 publications

(11 reference statements)

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“…However, no high-grade features have been described in SNRCLA including marked nuclear pleomorphism, high mitotic activity, hemorrhage, and necrosis. [ 1 – 3 , 8 , 11 ] Nevertheless, some tumors reportedly display infiltrative growth; the current case also showed deeply invasive growth within the dura. Compared to SNRCLA, neoplastic cells in clear cell RCC are arranged in solid nests separated by an intervening vascular network and may show high-grade Fuhrman nuclear features, frequent mitoses, and necrotic changes.…”

Section: Discussionmentioning

confidence: 55%

“…Clear cell RCC is usually negative for both CK7 and CK20 and shows positive expression for vimentin, CD10, RCC antigen, and CA9. [ 8 ] Also, the majority of clear cell RCC cases express nuclear PAX-2 and PAX-8. As summarized in Table 1 , most of the previously reported SNRCLA cases were positive for CK7 (9/10) and negative for vimentin (7/10).…”

Section: Discussionmentioning

confidence: 99%

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Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck

Kim

Yang²,

Kim³

et al. 2017

Medicine

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Rationale:Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm.Patient concerns:A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base.Diagnosis:The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach. Intraoperatively, a hypervascular paranasal mass invading the dura mater was removed en block. Histologically, the tumor resembled a clear cell renal cell carcinoma, with cuboidal shaped cells having clear cytoplasm. The tumor cells were positive for CK7, S100, vimentin and PAX-8 and negative for CD10 and PAX-2 by immunohistochemistry. No evidence of renal malignancy was found by radiological and clinical examinations.Interventions and outcomes:Following local radiation therapy, the patient was in good health without recurrence for 15 months after the operation.Lessons:To the best of the authors’ knowledge, this is the first reported case of SNRCLA in Korea. Because of its histological feature of clear cytoplasm, SNRCLA needs to be differentiated from clear cell renal cell carcinoma and other salivary clear cell carcinomas. The prognosis of SNRCLA is generally favorable as shown in the previously reported cases. Considering the limited number and follow-up periods of the cases, however, delayed recurrence should be kept in mind for clinicians.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck

Kim

Yang²,

Kim³

et al. 2017

Medicine

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“…In 2002, 2 independent case reports described unique, low‐grade sinonasal tumors with a clear cytoplasm that did not fit into any existing diagnostic category; both tumors were later described as sinonasal renal cell‐like adenocarcinoma. To date, a total of 16 possible patients, including our present case, have been identified (Table ) . The tumor has thus far been observed in 11 women and 5 men indicating that the cancer is twice as common in women as in men.…”

Section: Discussionmentioning

confidence: 97%

Sinonasal renal cell‐like adenocarcinoma: Easily misdiagnosed sinonasal tumor

Chuang

et al. 2018

Head & Neck

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“…SNRCLA is an extremely rare neoplasm, which only 19 cases have been reported in the English literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. SNRCLA was rst decribed as low grade adenocarcinoma of the nasal cavity and parenasal sinuses by heffner et al [2].…”

Section: Discussionmentioning

confidence: 99%

Primary sinonasal renal cell-like adenocarcinoma: a case report and review of the literature

Gou

Wang

Chen

et al. 2020

Preprint

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BackgroundPrimary sinonasal renal cell-like adenocarcinoma (SNRCLA) is an extremely rare neoplasm with unique clinical and pathological features. At present, there is no summary of its clinical and pathological characteristics. We treated one case and reported to here. Review the domestic and foreign literature, summarize its clinical pathological characteristics and diagnosis and treatment.CaseA 69-year-old female presented with repeated epistaxis, nasal obstruction of 2-years’ duration. Computed tomography (CT) was performed revealing an irregular mass of the right nasal cavity involving choana and nasopharynx. The patient was treated with endonasal endoscopic resection. Histologically, SNRCLA was very similar to clear cell renal cell carcinoma (RCC), the tumor cells were round or polygonal in size with abundant clear cytoplasm and uniform nuclei. The tumor cells positive for CK7, Vimentin, EMA, S-100, Ki-67 (5% +) and negative for CEA, P53, P63 by immunohistochemical staining,. The patient is free from recurrence over 27 months after the surgery.ConclusionSNRCLA seems to be a low-grade localized carcinoma associated with favorable prognosis. Surgical resection is recommended as the main stay of treatment.

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Sinonasal Clear Cell Adenocarcinoma

Cited by 9 publications

References 4 publications

Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck

Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck

Sinonasal renal cell‐like adenocarcinoma: Easily misdiagnosed sinonasal tumor

Primary sinonasal renal cell-like adenocarcinoma: a case report and review of the literature

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