Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck

Abstract

Rationale:Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm.Patient concerns:A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base.Diagnosis:The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach. Intraoperatively, a hypervascular paranasal mass invading the dura mater was removed en block. Histologically, the tumor resembled a clear cell renal cell carcinoma, with cuboidal shaped cells having clear cytoplasm. The tumor cells were positive for CK7, S100, vimentin and PAX-8 and negative for CD10 and PAX-2 by immunohistochemistry. No evidence of renal malignancy was found by radiological and clinical examinations.Interventions and outcomes:Following local radiation therapy, the patient was in good health without recurrence for 15 months after the operation.Lessons:To the best of the authors’ knowledge, this is the first reported case of SNRCLA in Korea. Because of its histological feature of clear cytoplasm, SNRCLA needs to be differentiated from clear cell renal cell carcinoma and other salivary clear cell carcinomas. The prognosis of SNRCLA is generally favorable as shown in the previously reported cases. Considering the limited number and follow-up periods of the cases, however, delayed recurrence should be kept in mind for clinicians.

Imaging Review of New and Emerging Sinonasal Tumors and Tumor-like Entities from the Fourth Edition of theWorld Health Organization Classification of Head and Neck Tumors

“…On MR imaging, the tumors are heterogeneous to the cortex on T2WI and enhance avidly, similar to renal cell carcinoma. [54][55][56] A key diagnostic criterion is the lack of a concomitant suspicious renal mass (Fig 9).…”

Primary sinonasal renal cell-like adenocarcinoma: a case report and review of the literature

“…SNRCLA is an extremely rare neoplasm, which only 19 cases have been reported in the English literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. SNRCLA was rst decribed as low grade adenocarcinoma of the nasal cavity and parenasal sinuses by heffner et al [2].…”

Sinonasal renal cell-like adenocarcinoma

“…Учитывая редкость и трудность диагностики СПКПА, данных об эпидемиологии недостаточно. Со времени ее первого описания насчитывается только 20 случаев СПКПА [3][4][5][6][8][9][10][11][12][13][14][15]. СПКПА -редкая опухоль, в основном встречается у пациентов в возрасте от 22 до 75 лет (в среднем -54 года), чаще у женщин [3][4][5].…”

“…При иммуногистохимическом исследовании клетки опухоли экспрессируют PanCytokeratin, CK7, EMA; экспрессия S100 вариабельна [3,8,9].…”

“…Известно, что в 2 из 20 описанных случаев возникали локальные рецидивы: у первого пациентачерез 7 мес., у второго -последовательно через 3 и 5 лет после хирургического лечения. Важно отметить, что лучевую терапию этим пациентам не проводили [8]. У остальных пациентов, подвергшихся хирургическому лечению и лучевой терапии, сохраняется полный ответ на проведенную терапию.…”