Sinonasal renal cell‐like adenocarcinoma: Easily misdiagnosed sinonasal tumor

Wu, Ching-Nung; Chuang, I-Chieh; Chuang, Ming-Jung; Chen, Wei-Chih

doi:10.1002/hed.25338

Cited by 7 publications

(4 citation statements)

References 9 publications

(13 reference statements)

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“…On MR imaging, the tumors are heterogeneous to the cortex on T2WI and enhance avidly, similar to renal cell carcinoma. [54][55][56] A key diagnostic criterion is the lack of a concomitant suspicious renal mass (Fig 9).…”

Section: Renal Cell-like Adenocarcinomamentioning

confidence: 99%

Imaging Review of New and Emerging Sinonasal Tumors and Tumor-like Entities from the Fourth Edition of theWorld Health Organization Classification of Head and Neck Tumors

Dean

Shatzkes

Phillips

2019

AJNR Am J Neuroradiol

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The sinonasal tract is an environment diverse with neoplasia. Given the continued discovery of entities generally specific to the sinonasal tract, the fourth edition of the World Health Organization Classification of Head and Neck Tumors was released in 2017. It describes 3 new, well-defined entities and several less-defined, emerging entities. The new entities are seromucinous hamartomas, nuclear protein in testis carcinomas, and biphenotypic sinonasal sarcomas. Emerging entities include human papillomavirus-related sinonasal carcinomas, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-deficient sinonasal carcinomas, renal cell-like adenocarcinomas, and chondromesenchymal hamartomas. The literature thus far largely focuses on the pathology of these entities. Our goal in this report was to familiarize radiologists with these new diagnoses and to provide available information regarding their imaging appearances. ABBREVIATIONS: HPV ϭ human papillomavirus; NUT ϭ nuclear protein in testis; NMC ϭ nuclear protein in testis midline carcinomas; SCC ϭ squamous cell carcinoma; SH ϭ seromucinous hamartoma; SWI/SNF ϭ SWItch/Sucrose Non-Fermentable; SMARCB1 ϭ SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SNUC ϭ sinonasal undifferentiated carcinoma; REAH ϭ respiratory epithelial adenomatoid hamartoma; WHO ϭ World Health Organization REVIEW OF HISTOLOGIC TYPES OF SINONASAL TUMORS Accurate interpretation of sinonasal tumor imaging by neuroradiologists necessitates a fundamental understanding of the histologic subtypes. Basic classification groups include squamous cell carcinomas (SCCs), adenocarcinomas, sarcomatous/mesenchymal tumors, neuroectodermal tumors, salivary neoplasms, papillomas, respiratory epithelial lesions, hematolymphoid tumors, and tumor-like entities (On-line Table).

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Section: Renal Cell-like Adenocarcinomamentioning

confidence: 99%

Imaging Review of New and Emerging Sinonasal Tumors and Tumor-like Entities from the Fourth Edition of theWorld Health Organization Classification of Head and Neck Tumors

Dean

Shatzkes

Phillips

2019

AJNR Am J Neuroradiol

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“…Eight, including our case, underwent additional RT and none received systemic therapy. Wu et al reported the only known case of local recurrence [ 9 ]. Their patient was treated with surgical excision alone and was found to have a recurrence 35 months after primary resection.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Renal Cell-Like Adenocarcinoma

Tokarz¹,

Favre²,

Belles³

2021

Cureus

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Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a newly defined, rare malignant tumor of the nasal cavity. The clinical course and response to treatment remain uncertain. The purpose of this study is to report a new case of SNRCLA and review the literature to determine clinical characteristics, treatment options, and outcomes. A 26-year-old male presented with headache, epistaxis, and nasal obstruction. Physical examination revealed a tumor involving bilateral ethmoid sinuses and MRI revealed extension through the cribriform plate. Surgical excision with endonasal and a bifrontal craniotomy was performed followed by adjuvant radiotherapy (RT). After RT, the patient had persistent disease requiring salvage surgery. There are few previously reported cases of SNRCLA. A literature review yielded 14 previously reported cases with convincing diagnostic evidence of SNRCLA. Common presenting symptoms were epistaxis and nasal obstruction. Surgical excision was the primary treatment in fourteen cases, nine received RT, and none received chemotherapy. However, three cases had persistent or recurrent disease. Surgical excision is the mainstay of treatment for SNRCLA and adjuvant RT has been used in some patients with varying outcomes. The tumor is low grade with no reported cases of metastases or death. The best practice for treatment is yet to be determined.

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“…SNRCLA is an extremely rare neoplasm, which only 19 cases have been reported in the English literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. SNRCLA was rst decribed as low grade adenocarcinoma of the nasal cavity and parenasal sinuses by heffner et al [2].…”

Section: Discussionmentioning

confidence: 99%

Primary sinonasal renal cell-like adenocarcinoma: a case report and review of the literature

Gou

Wang

Chen

et al. 2020

Preprint

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BackgroundPrimary sinonasal renal cell-like adenocarcinoma (SNRCLA) is an extremely rare neoplasm with unique clinical and pathological features. At present, there is no summary of its clinical and pathological characteristics. We treated one case and reported to here. Review the domestic and foreign literature, summarize its clinical pathological characteristics and diagnosis and treatment.CaseA 69-year-old female presented with repeated epistaxis, nasal obstruction of 2-years’ duration. Computed tomography (CT) was performed revealing an irregular mass of the right nasal cavity involving choana and nasopharynx. The patient was treated with endonasal endoscopic resection. Histologically, SNRCLA was very similar to clear cell renal cell carcinoma (RCC), the tumor cells were round or polygonal in size with abundant clear cytoplasm and uniform nuclei. The tumor cells positive for CK7, Vimentin, EMA, S-100, Ki-67 (5% +) and negative for CEA, P53, P63 by immunohistochemical staining,. The patient is free from recurrence over 27 months after the surgery.ConclusionSNRCLA seems to be a low-grade localized carcinoma associated with favorable prognosis. Surgical resection is recommended as the main stay of treatment.

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Sinonasal renal cell‐like adenocarcinoma: Easily misdiagnosed sinonasal tumor

Abstract: This is the first study to review the clinical features of sinonasal renal cell-like adenocarcinoma. We recommend surgical resection as the mainstay of treatment.

Cited by 7 publications

References 9 publications

Imaging Review of New and Emerging Sinonasal Tumors and Tumor-like Entities from the Fourth Edition of theWorld Health Organization Classification of Head and Neck Tumors

Imaging Review of New and Emerging Sinonasal Tumors and Tumor-like Entities from the Fourth Edition of theWorld Health Organization Classification of Head and Neck Tumors

Sinonasal Renal Cell-Like Adenocarcinoma

Primary sinonasal renal cell-like adenocarcinoma: a case report and review of the literature

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