Singlet‐Oxygen Oxidation of 5‐Hydroxymethylfurfural in Continuous Flow

Heugebaert, Thomas S. A.; Stevens, Christian V.; Kappe, C. Oliver

doi:10.1002/cssc.201403182

Cited by 58 publications

(50 citation statements)

References 26 publications

(18 reference statements)

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“…199 However, Kappe et al recently developed a continuous-flow procedure for the H 2 MF production to form 5-HMF. 200 The microreactor was built from commercially available PFA tubing (1 mm ID, 10 mL) and wrapped around a glass cylinder. As a light source, a 60 W compact fluorescent light bulb was employed.…”

Section: Homogeneous Catalysismentioning

confidence: 99%

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Liquid phase oxidation chemistry in continuous-flow microreactors

et al. 2016

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Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention as the reactor provides enhanced heat and mass transfer characteristics, safe use of hazardous oxidants, high interfacial areas, and scale-up potential. In this review, an up-to-date overview of both technological and chemical aspects of liquid phase oxidation chemistry in continuous-flow microreactors is given. A description of mass and heat transfer phenomena is provided and fundamental principles are deduced which can be used to make a judicious choice for a suitable reactor. In addition, the safety aspects of continuous-flow technology are discussed. Next, oxidation chemistry in flow is discussed, including the use of oxygen, hydrogen peroxide, ozone and other oxidants in flow. Finally, the scale-up potential for continuous-flow reactors is described.

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Section: Homogeneous Catalysismentioning

confidence: 99%

“…Singlet oxygen oxidation of 5-HMF in continuous flow. 200 Heterogeneous catalysis. Immobilization of photosensitizers for the production of singlet oxygen in microreactors can beneficial for several reasons (e.g., catalyst recuperation, high TON, easy work-up procedures).…”

Section: Homogeneous Catalysismentioning

confidence: 99%

Liquid phase oxidation chemistry in continuous-flow microreactors

et al. 2016

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“…A possible way to circumvent this in microreactors might be by the addition of an inert carrier phase in which the precipitated FDCA particles are dispersed, preventing them from interacting with the microreactor wall or solid catalysts. [292][293][294][295] Oxygenated monoterpenes are promising building blocks for the synthesis of pharmaceuticals, flavorants and fragrances. Some research has been done recently on the oxidation of HMF to FDCA using ionic liquids in which FDCA dissolves well, [287,288] however, the application of ionic liquids for industrial production is not economically feasible yet.…”

Section: Opportunitiesmentioning

confidence: 99%

Catalytic Transformation of Biomass Derivatives to Value‐Added Chemicals and Fuels in Continuous Flow Microreactors

2019

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Biomass as a renewable and abundantly available carbon source is a promising alternative to fossil resources for the production of chemicals and fuels. The development of biobased chemistry, along with catalyst design, has received much research attention over recent years. However, dedicated reactor concepts for the conversion of biomass and its derivatives are a relatively new research field. Continuous flow microreactors are a promising tool for process intensification, especially for reactions in multiphase systems. In this work, the potential of microreactors for the catalytic conversion of biomass derivatives to value-added chemicals and fuels is critically reviewed. Emphases are laid on the biphasic synthesis of furans from sugars, oxidation and hydrogenation of biomass derivatives. Microreactor processing has been shown capable of improving the efficiency of many biobased reactions, due to the transport intensification and a fine control over the process. Microreactors are expected to contribute in accelerating the technological development of biomass conversion and have a promising potential for industrial application in this area.

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“…Prompted by these encouraging results, a multitude of reactor designs -including microfluidic chip reactors [150], falling-film reactors [151], dual-and triplechannel microreactors [152,153], coil-based devices [154,155], gas-permeable micro-capillary films [156], and tube-in-tube membrane devices [157] -were subsequently applied for the generation and subsequent utilization of 1 O 2 in gas/liquid continuous flow regimes using well-known photosensitizers such as Rose Bengal, methylene blue, and porphyrins. Furthermore, it was shown that porphyrins can be immobilized on the channel wall of a glass microreactor to heterogeneously catalyze the formation of the reactive oxygen species [158].…”

Section: Oxidative Carbon-carbon Coupling Reactionsmentioning

confidence: 99%

Aerobic Oxidations in Continuous Flow

Pieber

Kappe

2015

Organometallic Flow Chemistry

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In recent years, the high demand for sustainable processes resulted in the development of highly attractive oxidation protocols utilizing molecular oxygen or even air instead of more uneconomic and often toxic reagents. The application of these sustainable, gaseous oxidants in conventional batch reactors is often associated with severe safety risks and process challenges especially on larger scales. Continuous flow technology offers the possibility to minimize these safety hazards and concurrently allows working in high-temperature/high-pressure regimes to access highly efficient oxidation protocols. This review article critically discusses recent literature examples of flow methodologies for selective aerobic oxidations of organic compounds. Several technologies and reactor designs for biphasic gas/liquid as well as supercritical reaction media are presented in detail.

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Singlet‐Oxygen Oxidation of 5‐Hydroxymethylfurfural in Continuous Flow

Cited by 58 publications

References 26 publications

Liquid phase oxidation chemistry in continuous-flow microreactors

Liquid phase oxidation chemistry in continuous-flow microreactors

Catalytic Transformation of Biomass Derivatives to Value‐Added Chemicals and Fuels in Continuous Flow Microreactors

Aerobic Oxidations in Continuous Flow

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