Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture

Shalumon, K.T.; Haridas, Anulekha K.; Girish, Chundayil Madathil; Prasanth, R.; Nair, Shantikumar V.; Jayakumar, R.

doi:10.1016/j.carbpol.2009.11.039

Cited by 201 publications

(124 citation statements)

References 34 publications

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“…The nanofibers are superior to PCL nanofibers in promoting bone tissue formation. Another fibrous scaffold comprising of chitosan and PCL was electrospun in a novel solvent consisting of formic acid and acetone [48]. This study indicated that optimized combination of chitosan (1%) and PCL (8%) was in 1:3 compositions.…”

Section: Electrospinning Of Blends Of Chitosan Andmentioning

confidence: 93%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

216

101

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Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

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Section: Electrospinning Of Blends Of Chitosan Andmentioning

confidence: 93%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

216

101

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“…Different methods are reported to produce biomimetic non-woven materials comprising a large network of interconnected fibers and pores (1,2). A large number of biomacromolecules, such as poly(ε-caprolactone), poly(lactic acid), poly(lactide-coglycoside), collagen, and gelatin have been successfully fabricated into non-woven mats by the electrospinning method (3)(4)(5). Especially, a series of electrospun nanofibers based on chitin and chitosan have gained a great attention owing to their extensive biomedical applications in such as tissue engineering scaffolds and drug delivery (6).…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of Cross-Linked Magnetic Chitosan Nanofibers for Protein Release

2015

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Abstract. A poly(vinylalcohol) (PVA) electrospun/magnetic/chitosan nanocomposite fibrous cross-linked network was fabricated using in situ cross-linking electrospinning technique and used for bovine serum albumin (BSA) loading and release applications. Sodium tripolyphosphate (TPP) and glutaraldehyde (GA) were used as cross-linkers which modified magnetic-Fe 3 O 4 chitosan as Fe 3 O 4/ CS/TPP and Fe 3 O 4/ CS/GA, respectively. BSA was used as a model protein drugs which was encapsulated to form Fe 3 O 4 /CS/TPP/BSA and Fe 3 O 4 /CS/GA/BSA nanoparticles. The composites were electrospun with PVA to form nanofibers. Nanofibers were characterized by field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FTIR). The characterization results suggest that Fe 3 O 4 nanoparticles with average size of 45 nm were successfully bound on the surface of chitosan. The cross-linked nanofibers were found to contain uniformly dispersed Fe 3 O 4 nanoparticles. The size and morphology of the nanofibers network was controlled by varying the cross-linker type. FTIR data show that these two polymers have intermolecular interactions. The sample with TPP cross-linker showed an enhancement of the controlled release properties of BSA during 30-h experimental investigation.

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“…However, all these solvents are relatively expensive compared with conventional solvent systems, and their nature may result in faster degradation of the polymers. 26 In this work, a CS-PCL copolymer was first prepared by grafting ε-caprolactone oligomers onto the hydroxyl groups of CS via ring-opening polymerization which was then blended with PCL to yield a 3-dimensional CS-PCL/PCL scaffold. The hypothesis was that the CS-PCL/PCL scaffolds would be easily fabricated by electrospinning their blend solutions in a common solvent system.…”

Section: Introductionmentioning

confidence: 99%

Electrospun chitosan-graft-poly (ε-caprolactone)/poly (ε-caprolactone) nanofibrous scaffolds for retinal tissue engineering

Chen¹,

Fan²,

Xia³

et al. 2011

IJN

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A promising therapy for retinal diseases is to employ biodegradable scaffolds to deliver retinal progenitor cells (RPCs) for repairing damaged or diseased retinal tissue. In the present study, cationic chitosan-graft-poly(ɛ-caprolactone)/polycaprolactone (CS-PCL/PCL) hybrid scaffolds were successfully prepared by electrospinning. Characterization of the obtained nanofibrous scaffolds indicated that zeta-potential, fiber diameter, and the content of amino groups on their surface were closely correlated with the amount of CS-PCL in CS-PCL/PCL scaffolds. To assess the cell–scaffold interaction, mice RPCs (mRPCs) were cultured on the electrospun scaffolds for 7 days. In-vitro proliferation assays revealed that mRPCs proliferated faster on the CS-PCL/PCL (20/80) scaffolds than the other electrospun scaffolds. Scanning electron microscopy and the real-time quantitative polymerase chain reaction results showed that mRPCs grown on CS-PCL/PCL (20/80) scaffolds were more likely to differentiate towards retinal neurons than those on PCL scaffolds. Taken together, these results suggest that CS-PCL/PCL(20/80) scaffolds have potential application in retinal tissue engineering.

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Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture

Cited by 201 publications

References 34 publications

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Electrospinning of Cross-Linked Magnetic Chitosan Nanofibers for Protein Release

Electrospun chitosan-graft-poly (ε-caprolactone)/poly (ε-caprolactone) nanofibrous scaffolds for retinal tissue engineering

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Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture

Cited by 201 publications

References 34 publications

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Electrospinning of Cross-Linked Magnetic Chitosan Nanofibers for Protein Release

Electrospun chitosan-graft-poly (&epsilon;-caprolactone)/poly (&epsilon;-caprolactone) nanofibrous scaffolds for retinal tissue engineering

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Product

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Electrospun chitosan-graft-poly (ε-caprolactone)/poly (ε-caprolactone) nanofibrous scaffolds for retinal tissue engineering