Electrospinning of Cross-Linked Magnetic Chitosan Nanofibers for Protein Release

Abstract

Abstract. A poly(vinylalcohol) (PVA) electrospun/magnetic/chitosan nanocomposite fibrous cross-linked network was fabricated using in situ cross-linking electrospinning technique and used for bovine serum albumin (BSA) loading and release applications. Sodium tripolyphosphate (TPP) and glutaraldehyde (GA) were used as cross-linkers which modified magnetic-Fe 3 O 4 chitosan as Fe 3 O 4/ CS/TPP and Fe 3 O 4/ CS/GA, respectively. BSA was used as a model protein drugs which was encapsulated to form Fe 3 O 4 /CS/TPP/BSA and Fe 3 O 4 /CS/GA/BSA nanoparticles. The composites were electrospun with PVA to form nanofibers. Nanofibers were characterized by field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FTIR). The characterization results suggest that Fe 3 O 4 nanoparticles with average size of 45 nm were successfully bound on the surface of chitosan. The cross-linked nanofibers were found to contain uniformly dispersed Fe 3 O 4 nanoparticles. The size and morphology of the nanofibers network was controlled by varying the cross-linker type. FTIR data show that these two polymers have intermolecular interactions. The sample with TPP cross-linker showed an enhancement of the controlled release properties of BSA during 30-h experimental investigation.

Structural and Surface Compatibility Study of Modified Electrospun Poly(ε-caprolactone) (PCL) Composites for Skin Tissue Engineering

“…The different synthetic polymers (11,12) such as polyglycolide (PGA) (13), polyvinyl pyrrolidone (PVP) (14), and their copolymers poly(lactide-co-glycolide) (PLGA) (15), poly(ε-caprolactone) (PCL) (16), and polyurethane (PU) (17) have been widely used in electrospinning process. Other natural polymers such as collagen, fibronectin, laminin, alginic acid, and chitosan can be also electrospun for producing nanofibrous scaffolds (18,19).…”

“…Nowadays, concepts of hybrid scaffolds have been started to avoid such limitations and use of both natural and synthetic polymers together to combine their good properties. When natural polymers such as collagen, fibronectin, laminin, alginic acid, and chitosan are electrospun and used alone, they can exhibit properties of the extracellular matrix (26) with excellent biocompatible surface enhancing the cell adhesion (18,19). However, such scaffolds are mechanically weak.…”

Magnetic Actuation Methods in Bio/Soft Robotics

“…This approach is a promising method for achieving controlled release of drug at specific cells. [ 349 ] MNPs combined with chitosan nanoparticles were also exposed to an alternating magnetic field. The challenge in using chitosan capsules is the ability to break the carrier or release the drug content once the capsule has reached its target.…”

The synthesis, mechanisms, and additives for bio‐compatible polyvinyl alcohol hydrogels: A review on current advances, trends, and future outlook

“…[ 13–15 ] With good biocompatibility, permeability, hydrophilicity and a low coefficient of friction, PVA hydrogels have been successfully used in artificial organs, [ 16–18 ] wound dressings, [ 19–22 ] shape memory hydrogel, [ 23–25 ] antibacterial applications, [ 26–28 ] flexible sensing devices [ 29–31 ] and sustained drug release carriers. [ 32–37 ]…”

“…[13][14][15] With good biocompatibility, permeability, hydrophilicity and a low coefficient of friction, PVA hydrogels have been successfully used in artificial organs, [16][17][18] wound dressings, [19][20][21][22] shape memory hydrogel, [23][24][25] antibacterial applications, [26][27][28] flexible sensing devices [29][30][31] and sustained drug release carriers. [32][33][34][35][36][37] Hydrogel materials play an important role in the biomedical field, but the relatively poor mechanical properties of most hydrogel materials (e.g., the tensile strength of hydrogels still does not reach the strength of biological tissues ($10 MPa) [5] ) largely limit their practical utility. Techniques for obtaining high-strength hydrogels by altering the microstructure of the material include constructing highly ordered internal structures in the network structure of hydrogels or by introducing chemical and physical cross-linking structures.…”