Single non-ionic surfactant based self-nanoemulsifying drug delivery systems: formulation, characterization, cytotoxicity and permeability enhancement study

Abstract

Single non-ionic surfactant based self-nanoemulsifying drug delivery system (SNEDDS) was formulated and characterised for poor water soluble drug, Atorvastatin calcium. Capmul MCM oil showing highest solubility for Atorvastatin calcium was selected as oil phase. Self-nanoemulsifying capacity of Cremophor RH 40, Cremophor EL, Tween 20, Tween 60, Tween 80 and Labrasol were tested for the selected oil. In vitro dissolution studies were performed and were characterized by t85% and dissolution efficiency (DE). Cytotoxicity of the formulations and permeation enhancement of the drug across caco-2 cell monolayer was assessed. Capmul MCM was found to be better nanoemulsified in decreasing order of Cremophor RH 40 > Cremophor EL > Tween 20 > Tween 60 > Tween 80. Values of droplet size (range 11-83 nm), polydispersity index (range 0.07-0.65); zeta potential (range -3.97 to -19.0) and cloud point (60-85°C) before and after drug loading proves the uniformity and stability of the formulations. SNEDDS formulated with Tween 20 surfactant showed enhanced dissolution with t85% and DE values at 10 min and 78.70, respectively. None of the formulation showed cytotoxicity at the concentration tested. Tween 20 based SNEDDS enhanced permeation of the drug as compared with pure drug across cell lines. It can be concluded that SNEDDS can be formulated by using single non-ionic surfactant system for enhance dissolution and absorption of poorly soluble drug, Atorvastatin calcium.

In vitro/in silicoapproach in the development of simvastatin-loaded self-microemulsifying drug delivery systems

“…As depicted in Table 3, the experimental values were within or close to the wide range of values found in literature [8,9,11]. It was assumed that propylene glycol monocaprylate has greater capacity to solubilize poorly water soluble drugs due to certain polarity of caprylic acid, as discussed in the previous study with atorvastatin [47].…”

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

“…The zeta potential of the optimum formulation was -20.90±1.47 mV as shown in table 5. The fatty acid content in the formula may cause the negative charge of the zeta potential [41].…”

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“…[22] Several studies have been published reporting MC glycerides for developing SEDDS of a wide variety of drugs. [23][24][25][26] According to these studies, being small molecular volume oil phase, medium chain glycerides showed the high solvent capacity and excellent miscibility with other surfactants and co-surfactants and enhanced the permeability and bioavailability of candidate drugs. While SCT, such as Triacetin, has not been widely explored for preparing SMEDDS.…”