Single Iron Site Nanozyme for Ultrasensitive Glucose Detection

Chen, Min; Zhou, Huang; Liu, Xiaokang; Yuan, Tongwei; Wang, Wenyu; Zhao, Chao; Zhao, Yafei; Zhou, Fangyao; Wang, Xin; Xue, Zhenggang; Yao, Takeshi; Xiong, Can; Wu, Yuen

doi:10.1002/smll.202002343

Cited by 117 publications

(68 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 13 , 14 , 15 , 16 ] In particular, the single‐atom nanozymes with atomically dispersed active metal centers are recently considered as a novel frontier due to their maximum utilization efficiency of metal atoms and high activity. [ 17 , 18 , 19 , 20 , 21 , 22 ] To our best acknowledge, ascorbate oxidase (AO) and APX are Cu and Fe containing metalloenzymes involves in redox reactions. The progression of the reactions is determined by the reactivity of the metals.…”

Section: Introductionmentioning

confidence: 99%

Atomically Dispersed Cu Nanozyme with Intensive Ascorbate Peroxidase Mimic Activity Capable of Alleviating ROS‐Mediated Oxidation Damage

et al. 2021

View full text Add to dashboard Cite

Ascorbate peroxidase (APX) as a crucial antioxidant enzyme has drawn attentions for its utilization in preventing cellsfrom oxidative stress responses by efficiently scavenging H 2 O 2 in plants. For eliminating the specific inactivation of natural APXs and regulating the catalytic activity, single-atom nanozymes are considered as promising classes of alternatives with similar active sites and maximal atomic utilization efficiency to natural APXs. Herein, graphitic carbon nitride (g-C 3 N 4 ) anchored with isolated single copper atoms (Cu SAs/CN) is designed as an efficient nanozyme with intrinsic APX mimetic behavior. The engineered Cu SAs/CN exhibits comparable specific activity and kinetics to the natural APXs. Based on the density functional theory (DFT), Cu-N 4 moieties in the active center of Cu SAs/CN are determined to exert such favorable APX catalytic performance, in which the electron transfer between Cu and coordinated N atoms facilitates the activation and cleavage of the adsorbed H 2 O 2 molecules and results in fast kinetics. The constructed Cu SAs/CN nanozyme with superior APX-like performance and high biocompatibility can be applied for effectively protecting the H 2 O 2 -treated cells against oxidative injury in vitro. These findings report the single-atom nanozymes as a successful paradigm for guiding nanozymes to implement APX mimetic performance for reactive oxygen species-related biotherapeutic.

show abstract

Section: Introductionmentioning

confidence: 99%

Atomically Dispersed Cu Nanozyme with Intensive Ascorbate Peroxidase Mimic Activity Capable of Alleviating ROS‐Mediated Oxidation Damage

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Given that the peroxidase‐like nanozyme‐glucose (GOx) biocatalytic cascade platform, the authors embedded all biosensor ingredients (TMB, GOx, and Fe SSN) into the agarose‐based hydrogel to broaden its practicality. [ 213 ]…”

Section: Applications Of Single‐atom Catalystsmentioning

confidence: 99%

Synthesis Strategies, Catalytic Applications, and Performance Regulation of Single‐Atom Catalysts

Jung

et al. 2021

Adv Funct Materials

152

106

View full text Add to dashboard Cite

The recent dramatic increase in research on isolated metal atoms has received extensive scientific interest in the new frontier of single‐atom catalysis. As newly advanced materials in catalysis, single‐atom catalysts (SACs) have received enormous interest from the perspectives of both scientific research and industrial applications due to their remarkable activity. In addition, other catalytic properties of single metal atoms, including stability and selectivity, can be further improved by tuning their electronic/geometric structures and modulating the metal–support interactions. SACs usually consist of dispersed atoms and appropriate support materials, which are employed to anchor, confine, and/or coordinate with isolated metal atoms. Therefore, the nature of single metal sites allows acquiring a maximum atom utilization approaching 100%, which is of significance, particularly for the development of noble‐metal‐based catalysts. In order to systematically understand the structure–property relationships and the underlying catalytic mechanisms relationship of SACs, the representative scientific research efforts in their synthesis strategies, catalytic applications, and performance regulation are discussed here. Typical single‐atom catalysis processes and the corresponding mechanisms in electrochemistry, photochemistry, organic synthesis, and biomedicine are also summarized. Finally, the challenges and prospects for the development of single‐atom catalysis and SACs are highlighted.

show abstract

“…Reproduced with permission. [ 95 ] Copyright 2020, WILEY‐VCH. G) Schematic illustration of peroxidase‐like activities of JFSNs in catalysis of TMB−H 2 O 2 system and using GOx‐JFSNs as biosensing platforms for colorimetric detection of H 2 O 2 and glucose.…”

Section: Nanomaterials For Diabetes Diagnosismentioning

confidence: 99%

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

View full text Add to dashboard Cite

Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

show abstract

Single Iron Site Nanozyme for Ultrasensitive Glucose Detection

Cited by 117 publications

References 32 publications

Atomically Dispersed Cu Nanozyme with Intensive Ascorbate Peroxidase Mimic Activity Capable of Alleviating ROS‐Mediated Oxidation Damage

Atomically Dispersed Cu Nanozyme with Intensive Ascorbate Peroxidase Mimic Activity Capable of Alleviating ROS‐Mediated Oxidation Damage

Synthesis Strategies, Catalytic Applications, and Performance Regulation of Single‐Atom Catalysts

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Contact Info

Product

Resources

About