Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars

Wang, Shouju; Huang, Peng; Nie, Liming; Xing, Ruijun; Liu, Dingbin; Wang, Zhe; Lin, Jing; Chen, Shouhui; Niu, Gang; Lu, Guangming; Chen, Xiaoyuan

doi:10.1002/adma.201204623

Cited by 473 publications

(368 citation statements)

References 36 publications

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“…[7][8][9][10][11][12][13] Recently, gold nanoparticles (NPs) have also been conceived as contrast agents of X-ray imaging for cancer therapy, because of their enhancement effects in photoelectronic absorption and secondary electron generation. [14][15][16][17] Compared with other novel therapy methods, radiation therapy is closely related to clinical application which means that it is necessary to accept more rigorous topological examination and toxicological observation for gold nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Chen

Wang²,

Long³

et al. 2013

IJN

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Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used to observe the general toxicity of reproductive organs. The immune response was influenced significantly in female mice, with obvious changes in spleen and thymus index. Hematology results showed that male mice treated with 22.5 nm gold nanoparticles received more significant infection and inflammation than female mice. Meanwhile, the biochemistry results showed that 4.4 and 22.5 nm gold nanoparticles caused more significant liver damage in male mice than female mice, while 22.5, 29.3, and 36.1 nm gold nanoparticles caused more significant kidney damage in female mice than male mice. No significant toxicological response was found in the reproductive system for female or male mice. It was found that gold nanoparticles caused more serious liver toxicity and infection in male mice than female mice. These findings indicated that sex differences may be one of the important elements for in vivo toxicity of gold nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Chen

Wang²,

Long³

et al. 2013

IJN

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“…NPs for dual-modality of fluorescence and magnetic resonance imaging-guided, and dual-therapy using photothermal therapy (PTT) and photodynamic therapy (PDT) have been developed recently [11][12][13][14][15][16][17][18][19][20][21][22], where synergic treatment modalities combining PDT with PTT could overcome current limitations of PDT, thus achieving enhanced anticancer efficacy.…”

Section: Introductionmentioning

confidence: 99%

Progress of nanotechnology for phototherapy: Fundamentals and applications

Lin¹,

Chen²,

Liu³

2017

Med Devices Diagn Eng

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“…Photosensitizers are not toxic to cells without laser irradiation. 8 PDT improves selectivity of anticancer agents and also decreases their side effects, compared to conventional radiotherapies and chemotherapies. 9 Recently, photochemical internalization, an application of PDT, has been employed to improve the chemotherapeutic effect in cancers with MDR.…”

Section: Et Almentioning

confidence: 99%

Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

Li¹,

Cai²,

Zhao³

et al. 2017

IJN

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Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly( d , l -lactide-co-glycolide)–poly(ethylene glycol)–poly( d , l -lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light. MIT-PFP/PPP mixed micelles showed effective interaction with near-infrared light at the wavelength of 660 nm and exerted great cytotoxicity in MCF-7/ADR cells with irradiation. Furthermore, MIT-PFP/PPP mixed micelles could improve reactive oxygen species (ROS) levels, decrease P-glycoprotein activity, and increase the cellular uptake of drugs with improved intracellular drug concentrations, which induced cell apoptosis in MCF-7/ADR cells under irradiation, despite MDR effect, as indicated by the increased level of cleaved poly ADP-ribose polymerase. These findings suggested that MIT-PFP/PPP mixed micelles may become a promising strategy to effectively reverse the MDR effect via photodynamic therapy in breast cancer.

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Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars

Cited by 473 publications

References 36 publications

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Progress of nanotechnology for phototherapy: Fundamentals and applications

Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

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