Progress of nanotechnology for phototherapy: Fundamentals and applications

Lin, Jenn-Wei; Chen, Kuo-Ti; Liu, Hsia‐Wei

doi:10.15761/mdde.1000124

Cited by 8 publications

(9 citation statements)

References 36 publications

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“…Substantial bactericidal activity is seen for both polymers. For Gram‐negative E. coli, lipopolysaccharides containing negatively charged carboxyl groups and inorganic phosphates may provide points of interaction for P3HT‐T and P3HT‐Im leading to membrane damage . This is independent of polymer functionalization and light condition.…”

Section: Resultsmentioning

confidence: 99%

Size and Substitution Effect on Antimicrobial Activity of Polythiophene Polyelectrolyte Derivatives Under Photolysis and Dark Conditions

Brown

Yang

Strach

et al. 2018

Photochem & Photobiology

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Cationic polythiophenes have been shown to be potent antimicrobial compounds due to their ability to absorb visible light and sensitize the production of reactive oxygen species (ROS) as well as their ability to selectively associate with and damage negatively charged cell envelopes. This study demonstrates the ability of differentially sized imidazolium- and tertiary amine-functionalized poly(3-hexylthiophene) (P3HT) to inactivate Gram-negative Escherichia coli and Gram-positive Bacillus atrophaeus under photolysis and dark conditions. Flow cytometry viability assays are used to quantify cell death. Each compound shows high levels of killing at both 1 and 10 μg mL polymer concentrations for each microbial species after photoactivation as well as high levels of dark inactivation in many cases. Tertiary amine-functionalized P3HT is shown to have different killing patterns, shown by transmission electron microscopy, compared to the imidazolium-functionalized derivatives.

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Section: Resultsmentioning

confidence: 99%

Size and Substitution Effect on Antimicrobial Activity of Polythiophene Polyelectrolyte Derivatives Under Photolysis and Dark Conditions

Brown

Yang

Strach

et al. 2018

Photochem & Photobiology

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“…Synergic method combining photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers were also reported [2][3][4]. Besides the synergic methods, improvement of the efficacy of anti-cancer also include the use of nano-medicine and nanoparticles [5]. The efficacy of PDT may be further improved significantly via conjugated nanogolds.…”

Section: Introductionmentioning

confidence: 99%

Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy

Lin¹

2018

NACS

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The kinetics and efficacy of anti-cancer via phototherapy are reviewed. Factors influencing the cancer therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers (PS), respectively, are analyzed. Efficacy of cancer therapy may be enhanced by combining PTT and PDT either activated by one light or two lights. For maximum PTT/PDT synergistic efficacy, the concentration of photosensitizers and nanogold required optimization, besides the wavelength of the light matching the absorption peak of PS and nanogold, and the sequential order of PTT and PDT process. External supply of either photosensitizers or oxygen concentration will significantly improve the anti-cancer efficacy via type-II PDT. The singlet oxygen threshold dose for PDT and cell viability are governed by the product of PS concentration and light dose.

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“…Lights (lasers and LEDs) have been used for various medical procedures such as dermatology and cosmetic surgery, wound healings, nerve stimulation, dentistry ophthalmology applications for vision corrections and corneal deceases, and many other therapeutic procedures [1][2][3]. Combining the nanoparticles, diode lasers have been also used for cancer therapy, bio-sensing, bioimaging, drug delivery, tissue engineering and diagnostics of cancer cell [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%