Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

Li, Zeyong; Cai, Yuee; Zhao, Yiqiao; Yu, Hua; Zhou, Haiyu; Chen, Meiwan

doi:10.2147/ijn.s138235

Cited by 20 publications

(9 citation statements)

References 24 publications

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“…Therefore, the lysosome/endosomal escape of PMs was the key to their operative treatment. At present, a variety of techniques such as the proton sponge effect, photochemical internalization and lysosome/endosomal membrane-selective destabilization could mediate the escape of PMs [40][41][42]. For instance, PMs with excess tertiary amines induced chloride ions and water influx into the lysosome/endosome, and eventually resulted in cracked lysosome/endosome.…”

Section: Intracellular Trafficking Of Polymer Micellesmentioning

confidence: 99%

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Ning

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Polymeric micelles (PMs) play a vital role in multidrug co-delivery and cancer treatment. However, development of intelligent PMs further allows PMs to accurately target tumour, selectively release cargo multidrug and increase uptake. Therefore, targets, controlled release and uptake of intelligent PMs should be paid more attention to improvement of synergistic therapeutic outcomes and minimize side effects. In this review, tumour targeting of co-delivery intelligent PMs and its intracellular trafficking mechanisms were overviewed. And this review provides a comprehensive summarization of several intelligent co-delivery PMs. Such a system could control the multidrug to be released simultaneously or sequentially by special properties of tumour microenvironment (TME) (including acidic PH, redox, overexpressed enzyme, excessive temperature) and external environment trigger. Additionally, limitations, clinical translation and future perspectives of intelligent co-delivery PMs were also being discussed in this article.

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Section: Intracellular Trafficking Of Polymer Micellesmentioning

confidence: 99%

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Ning

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Briefly, the MDA-MB-231, MCF-7 cells were seeded into 24-well plate at a density of 1 Â 10 4 cells per well and cultured for 24 h. Then, the medium was replaced with fresh medium containing curloaded ALN-oHA-S-S-CUR micelles or cur-loaded oHA-CUR micelles (cur concentration: 20 lg/ml) and was cultured for 2 and 4 h at 37 C in a humidified atmosphere containing 5% CO 2 . Finally, the cells were rinsed thrice with PBS (pH: 7.4) and fixed with 4% paraformaldehyde for 15 min, rinsed again with PBS [23]. The uptake was visualized by inverted fluorescence microscope.…”

Section: Cell Uptake Studymentioning

confidence: 99%

Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation

Dong

Zou

Guo

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The traditional therapy of cancer has systemic side effects, and many cancers, such as human breast cancer and lung cancer easily metastasize to bones, leading to the formation of secondary tumours. This study was aimed at enhancing the anti-tumour effect of curcumin (CUR) and preventing tumour spread to the bone. A novel multifunctional redox-responsive and CD44 receptor targeting polymer-drug, poly alendronate-hyaluronan-S-S-curcumin copolymer (ALN-oHA-S-S-CUR) based CUR and alendronate (ALN) were synthesized successfully with the disulphide bond linker. The structure of ALN-oHA-S-S-CUR was characterized by H-NMR. The nanomedicine had natural anti-tumour drugs (CUR) as the hydrophobic kernel, and targeting CD44 receptor oligosaccharides of hyaluronan (oHA) and other anti-tumour drugs (ALN) as hydrophilic shell, named ALN-oHA-S-S-CUR conjugates, which could self-assemble into micelle-like nano-spheres in water via a dialysis method with hydrodynamic diameters of 179 ± 23 nm. Interestingly, the cur-loaded ALN-oHA-S-S-CUR micelles were stable in PBS but were capable of releasing the drug under the reducing environment. The rate of drug release was proportional to the GSH concentration. The uptake and cytotoxicity of micelles were higher in MDA-MB-231 cells than in MCF-7 cells because of a higher expression of the CD44 receptor in the former cell line. And compared to the cur-loaded oHA-CUR micelles, the cur-loaded ALN-oHA-S-S-CUR micelles had a good cellular uptake in 2D cancer cell and penetrability in 3D cancer cell spheroids. These results indicated the active targeting redox-sensitive micelles were promising as intracellular drug delivery systems for cancer treatment.

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“…In 2015, Yang et al [ 41 ] were the first to introduce multifunctional chemo-PDT and fluorescent imaging systems based on mesoporous silica NPs. Subsequently, many types of NPs and PSs were analyzed for the purpose of improving the therapeutic efficacy of PDT and chemotherapy, not only against the multidrug resistant cancer cells [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ], but also against the cancer stem cell phenotype [ 58 , 59 , 60 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer

et al. 2022

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It is more than sixty years since the era of modern photodynamic therapy (PDT) for cancer began. Enhanced selectivity for malignant cells with a reduced selectivity for non-malignant cells and good biocompatibility along with the limited occurrence of side effects are considered to be the most significant advantages of PDT in comparison with conventional therapeutic approaches, e.g., chemotherapy. The phenomenon of multidrug resistance, which is associated with drug efflux transporters, was originally identified in relation to the application of chemotherapy. Unfortunately, over the last thirty years, numerous papers have shown that many photosensitizers are the substrates of efflux transporters, significantly restricting the effectiveness of PDT. The concept of a dynamic nanoplatform offers a possible solution to minimize the multidrug resistance effect in cells affected by PDT. Indeed, recent findings have shown that the utilization of nanoparticles could significantly enhance the therapeutic efficacy of PDT. Additionally, multifunctional nanoplatforms could induce the synergistic effect of combined treatment regimens, such as PDT with chemotherapy. Moreover, the surface modifications that are associated with nanoparticle functionalization significantly improve the target potential of PDT or chemo-PDT in multidrug resistant and cancer stem cells.

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Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

Cited by 20 publications

References 24 publications

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation

Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer

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