Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Yu, Guangping; Ning, Qian; Mo, Zhengcheng; Tang, Shengsong

doi:10.1080/21691401.2019.1601104

Cited by 64 publications

(27 citation statements)

References 130 publications

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“…These include quantum dots [2], dendrimers [3], magnetic nanoparticles [4][5][6], solid-lipid nanoparticles [7][8][9], ceramic nanoparticles [3], colloidal nanoliposomes [10], polymeric and functionalized polymeric nanoparticles [11,12], metal and inorganic nanoparticles [13], phospholipid micelles [14], and polymeric micelles [15]. Over the past few decades, a number of drug delivery systems have been introduced to improve the treatment of various disorders and diseases.…”

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confidence: 99%

Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Srivastava

Prajapati

2020

Asian Biomedicine

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The inherent properties of albumin facilitate its effective use as a raw material to prepare a nanosized drug delivery vehicles. Because of the enhanced surface area, biocompatibility, and extended half-life of albumin nanoparticles, a number of drugs have been incorporated in albumin matrices in recent years. Furthermore, its ability to be conjugated to various receptor ligands makes albumin an ideal candidate for the increased delivery of drugs to specific sites. The present review provides an in-depth discussion of production strategies for the preparation of albumin and conjugated albumin nanoparticles and for the targeting of these formulations to specific organs and cancer cells. This review also provides insights into drug loading, release patterns, and cytotoxicity of various drug-loaded albumin nanoparticles.

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confidence: 99%

Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Srivastava

Prajapati

2020

Asian Biomedicine

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“…[90]. In their review, Yu et al have shown that, the polymeric micelles with intelligent response to different stimuli can be a promising approach for multi-drug co-delivery and control release [91]. Their loading onto textile materials may allow obtaining in the future materials for successful local or transdermal treatment.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

2021

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Textile materials, as a suitable matrix for different active substances facilitating their gradual release, can have an important role in skin topical or transdermal therapy. Characterized by compositional and structural variety, those materials readily meet the requirements for applications in specific therapies. Aromatherapy, antimicrobial substances and painkillers, hormone therapy, psoriasis treatment, atopic dermatitis, melanoma, etc., are some of the areas where textiles can be used as carriers. There are versatile optional methods for loading the biologically active substances onto textile materials. The oldest ones are by exhaustion, spraying, and a pad-dry-cure method. Another widespread method is the microencapsulation. The modification of textile materials with stimuli-responsive polymers is a perspective route to obtaining new textiles of improved multifunctional properties and intelligent response. In recent years, research has focused on new structures such as dendrimers, polymer micelles, liposomes, polymer nanoparticles, and hydrogels. Numerous functional groups and the ability to encapsulate different substances define dendrimer molecules as promising carriers for drug delivery. Hydrogels are also high molecular hydrophilic structures that can be used to modify textile material. They absorb a large amount of water or biological fluids and can support the delivery of medicines. These characteristics correspond to one of the current trends in the development of materials used in transdermal therapy, namely production of intelligent materials, i.e., such that allow controlled concentration and time delivery of the active substance and simultaneous visualization of the process, which can only be achieved with appropriate and purposeful modification of the textile material.

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“…84,85 Micelles Self-assembled polymeric micelles have received growing attention in the field of drug delivery systems in recent years owing to the ability of drug solubilization, sustained drug release and drug targeting. 86 Polymeric micelles consist of amphiphilic block copolymers, having a hydrophilic shell and a hydrophobic core, which can be used as a promising drug delivery system for the hydrophobic drugs. 87 Table 1 has listed the micelles encapsulated with GA.…”

Section: Nano-scale Drug Delivery Systemsmentioning

confidence: 99%

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Liu

Chen

Lin

et al. 2020

IJN

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Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

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Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Cited by 64 publications

References 130 publications

Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

Gambogic Acid as a Candidate for Cancer Therapy: A Review

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