Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

Abstract

Textile materials, as a suitable matrix for different active substances facilitating their gradual release, can have an important role in skin topical or transdermal therapy. Characterized by compositional and structural variety, those materials readily meet the requirements for applications in specific therapies. Aromatherapy, antimicrobial substances and painkillers, hormone therapy, psoriasis treatment, atopic dermatitis, melanoma, etc., are some of the areas where textiles can be used as carriers. There are versatile optional methods for loading the biologically active substances onto textile materials. The oldest ones are by exhaustion, spraying, and a pad-dry-cure method. Another widespread method is the microencapsulation. The modification of textile materials with stimuli-responsive polymers is a perspective route to obtaining new textiles of improved multifunctional properties and intelligent response. In recent years, research has focused on new structures such as dendrimers, polymer micelles, liposomes, polymer nanoparticles, and hydrogels. Numerous functional groups and the ability to encapsulate different substances define dendrimer molecules as promising carriers for drug delivery. Hydrogels are also high molecular hydrophilic structures that can be used to modify textile material. They absorb a large amount of water or biological fluids and can support the delivery of medicines. These characteristics correspond to one of the current trends in the development of materials used in transdermal therapy, namely production of intelligent materials, i.e., such that allow controlled concentration and time delivery of the active substance and simultaneous visualization of the process, which can only be achieved with appropriate and purposeful modification of the textile material.

A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris

“…Thermo-responsive hydrogels are hydrogels that respond to temperature as a stimulus [24]. Thermo-responsive hydrogels synthesized from natural polymers are more advantageous, as they are biocompatible and biodegradable as compared to their synthetic counterparts [25].…”

Antimicrobial textile: recent developments and functional perspective

“…Beside antimicrobial substances, these textiles may be used as carrier in aromatherapy, atopic dermatitis, painkillers, hormone therapy, melanoma, psoriasis treatment, etc. [ 85 ]. Recent study suggested that lyocell and antimicrobial silver-impregnated textiles are promising on common atopic dermatitis [ 86 ].…”

Review of Applications and Future Prospects of Stimuli-Responsive Hydrogel Based on Thermo-Responsive Biopolymers in Drug Delivery Systems

“…The double layer fabric with an outer layer of polypropylene (15%) and an inner layer of nylon (72.5%) with polyurethane (12.5%) showed better transdermal delivery of rhodamine B base and caffeine than control clothing made of pure organic cotton [ 79 ]. The modification of textile fabrics with thermo-responsive hydrogels as drug carriers is a recent approach to develop bio-functional textiles, and these materials can improve the condition of patients with atopic dermatitis through textile-based transdermal therapy, which offers the sustained and timely delivery of drug molecules to the affected areas on the skin [ 80 ]. The thermo-responsive micro-hydrogel made of poly( N -isopropylacrylamide) was developed from an inverse suspension polymerization method, and the procaine-loaded micro-hydrogel system was used for the designing of bio-functional textiles [ 81 ].…”