A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris

Abstract

Psoriasis vulgaris (PV) is a common chronic disease, affecting much of the population. Hydrocortisone (HCT) is currently utilized as a PV treatment; however, it is associated with undesirable side effects. The aim of this research was to create a thermo-responsive nano-hydrogel delivery system. HCT-loaded sorbitan monostearate (SMS)-polycaprolactone (PCL) nanoparticles, encapsulated with thermo-responsive hydrogel carboxymethyl cellulose (CMC), were synthesized by applying the interfacial polymer-deposition method following solvent displacement. The nanoparticles’ properties were evaluated employing Differential Scanning Colorimetry, Thermogravimetric Analysis, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Zeta sizer, Ultraviolet/Visual spectroscopy, and cytotoxicity testing. The nanoparticle sizes were 110.5 nm, with polydispersity index of 0.15 and zeta potential of −58.7 mV. A drug-entrapment efficacy of 76% was attained by the HCT-loaded SMS-PCL nanoparticles and in vitro drug-release profiles showed continuous drug release over a period of 24 hrs. Keratinocyte skin cells were treated with HCT-loaded SMS-PCL nanoparticles encapsulated with CMC; the results indicated that the synthesized drug-delivery system was less toxic to the keratinocyte cells compared to HCT. The combined trials and results from the formulation of HCT-loaded SMS-PCL nanoparticles encapsulated with CMC showed evidence that this hydrogel can be utilized as a potentially invaluable formulation for transdermal drug delivery of HCT, with improved efficacy and patient conformity.

Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches for Prolonged and Intelligent Psoriasis Management

“…Thus, we kept the molar ratio between PBA of HP and EGCG as 1:1 in the following study. It has been reported that psoriatic skins are characterized by elevated ROS levels and acidic pH. , To investigate the ROS-responsive properties of EGCG-HP gel, we incubated gels in PBS buffers (pH 7.4) with different H 2 O 2 concentrations (0, 0.2, 0.5, and 1 mM). The gel was completely dissolved after incubating in 0.5 or 1 mM H 2 O 2 for 24 h, while the gel in a PBS buffer (pH 7.4) without H 2 O 2 remained nearly unchanged (Figure S4).…”

“…The evaluated ROS and acidic pH triggered the release of EGCG from the gel needle tips in psoriatic skin (Scheme 1b). 38 As the cross-linked gel needle tips remained in the skin for about 4 days, a more sustained release of EGCG was achieved. The released EGCG scavenged ROS in psoriatic lesions, alleviating inflammation in the psoriasis microenvironment by inhibiting NF-κB inflammation pathways of keratinocytes (Scheme 1c).…”

“…As a result, MTX was quickly released from porous needle tips diffusively to provide timely treatment for psoriasis. The evaluated ROS and acidic pH triggered the release of EGCG from the gel needle tips in psoriatic skin (Scheme b) . As the cross-linked gel needle tips remained in the skin for about 4 days, a more sustained release of EGCG was achieved.…”

Hydrocortisone-Loaded Lipid–Polymer Hybrid Nanoparticles for Controlled Topical Delivery: Formulation Design Optimization and In Vitro and In Vivo Appraisal

“…55,56 In addition, HCA acts as a vasoconstrictor within the upper layers of the skin, which indirectly decreases the inflammation by minimizing the blood flow to the inflammation site. 6 Application of the optimized formulation (Figure 9D) induced a higher healing effect when compared to both toxic and HCA solution-treated groups through exhibiting a low density of neutrophils. In addition, the ear chiefly restored its normal architecture after treatment.…”

“…5 Hydrocortisone is a category V−VII, low-to-intermediatepotency corticosteroid with excellent anti-inflammatory and vasoconstrictive effects. 6 It was the first drug of the synthetic corticosteroid category that was utilized in local skin formulations for this indication. However, addition of the acetate group to its structure was reported to enhance the local activity fivefold.…”