The inherent properties of albumin facilitate its effective use as a raw material to prepare a nanosized drug delivery vehicles. Because of the enhanced surface area, biocompatibility, and extended half-life of albumin nanoparticles, a number of drugs have been incorporated in albumin matrices in recent years. Furthermore, its ability to be conjugated to various receptor ligands makes albumin an ideal candidate for the increased delivery of drugs to specific sites. The present review provides an in-depth discussion of production strategies for the preparation of albumin and conjugated albumin nanoparticles and for the targeting of these formulations to specific organs and cancer cells. This review also provides insights into drug loading, release patterns, and cytotoxicity of various drug-loaded albumin nanoparticles.
The catalytic effect of ruthenium chloride on the outer sphere electron transfer of hexacyanoferrate(II) by periodate ion in aqueous alkaline medium has been effectively employed to determine ruthenium(III) at micro level. The optimum reaction condition has been established and fixed time procedure is adopted. A linear relationship between changes in absorbance and added Ru(III) concentration has been utilized for the trace level determination of Ru(III). The results reveal that the addition of interfering ions (up to 71 times higher concentration of Ru) does not have significant effect on the catalytic activity of Ru(III) on oxidation of hexacyanoferrate(II) by periodate ion. Polyaminocarboxylates (HEDTA, EDTA and IDA) suppress its catalytic power to maximum, if tolerance limit is more than 14.29 times. Due to the reproducibility, stability and selectivity, this method can also be quantitatively applied in different types of water samples for determination of ruthenium(III) at micro level.
In Municipal solid waste disposal is a burning issue around the world. Increase of the population and change in lifestyle are finding their way out to manage for a fight quantum increase in MSW. Due to least priority of the governing body in developing country like India, it is much tougher to have a sustainable management system for MSW. Town in India is characterizing as per population. This paper gives detail studied with segregation and sustainable management of waste composition was suggested for MSW in the medium scale town of the south Gujarat region in India. Route study of the MSW transportation is also done so as optimum route can be suggested with the quantity of waste in minimum cost.
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