A modified method for the production of stable surface-functionalized bovine serum albumin nanoparticles

Srivastava, Abhishek; Prajapati, Anjali; Pramanik, Panchanan; Singh, Vinay

doi:10.4103/bbrj.bbrj_125_21

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…To prevent the potential for formed nanoparticles to aggregate, the FEA colloidal solution needs to be stirred [46][47][48]. Previous studies have shown that in order to produce albumin particles with a size in the nanometer range, a stirring rate of at least 450 rpm is necessary [43,49]. To fabricate stable FEA nanoparticles of the desired size, ethanol was added dropwise to a 60 mg/ml aqueous solution of FEA at pH 7 while stirring at speeds ranging from 200 to 850 rpm.…”

Section: Influence Of Stirring Rate On Zeta Potential and Particle Di...mentioning

confidence: 99%

Preparation and encapsulation efficiency of surface modified egg albumin nanoparticles

SRIVASTAVA¹,

SRIVASTAVA²,

SRIVASTAVA³

2023

jrp

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A biocompatible nano-drug delivery vehicle can efficiently deliver the toxic drug to the targeted site in nano-quantity to treat cancer patients. Considering this, the current study aims to fabricate stable egg albumin nanoparticles by using chloroacetic acid to modify their surfaces. The carboxyl functionalized egg albumin (FEA) nanoparticles were prepared through the desolvation process using ethanol as the desolvating agent; the generated nanoparticles were stabilized by glutaraldehyde. To obtain stable nanoparticles of suitable size, various reaction parameters viz concentration of FEA, pH, agitation speed, glutaraldehyde concentration, and rate of ethanol addition were examined. In neutral and alkaline mediums, we can get nanoparticles of 120-160 nm with -32 mV zeta potential. The pH of the medium played a decisive role, which strongly influences the FEA particle diameter and surface charge, while other parameters show little influence. SEM monochrome image of functionalized EA nanoparticles also supported the particle size of around 130 nm. Gallic acid (GA) has been encapsulated under optimal desolvation conditions using the FEA/GA acid ratios of 1:1, 2:1, 4:1, and 8:1. The obtained GA entrapped FEA spherical nanoparticles (GA-FEA) had a -30.9mV zeta potential and were negatively charged. At a 2:1 polymer/drug ratio, an entrapment efficiency (EE) of 90.4 % (w/w) and drug loading capacity of about 28.7 % (w/w) were achieved. This work is beneficial to the scientists involved in the field of cancer research.

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Section: Influence Of Stirring Rate On Zeta Potential and Particle Di...mentioning

confidence: 99%

Preparation and encapsulation efficiency of surface modified egg albumin nanoparticles

SRIVASTAVA¹,

SRIVASTAVA²,

SRIVASTAVA³

2023

jrp

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A comparative study of cross-linked human serum albumin nanoparticles using ultrasonication or glutaraldehyde; The impact on the corona protein adsorption using SDS-PAGE and MALDI-TOF

Malekizadeh,

Rafati

2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Albumin-stabilized polydopamine nanoparticles for chemo-photothermal synergistic therapy of melanoma

Wang

et al. 2023

Journal of Drug Delivery Science and Technology

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A modified method for the production of stable surface-functionalized bovine serum albumin nanoparticles

Cited by 3 publications

References 36 publications

Preparation and encapsulation efficiency of surface modified egg albumin nanoparticles

Preparation and encapsulation efficiency of surface modified egg albumin nanoparticles

A comparative study of cross-linked human serum albumin nanoparticles using ultrasonication or glutaraldehyde; The impact on the corona protein adsorption using SDS-PAGE and MALDI-TOF

Albumin-stabilized polydopamine nanoparticles for chemo-photothermal synergistic therapy of melanoma

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