“…AD lesional skin is characterized by a defective skin barrier and a type-2‒dominated local immune response ( Weidinger et al., 2018 ). AD skin lesions demonstrate increased expression of type-2‒promoting epithelial cytokines IL-33, TSLP, and IL-25 and increased numbers of type 2 innate lymphoid cells (ILC2s) that express high levels of receptors for these cytokines ( Alkon et al., 2021 ; Kim et al., 2013 ; Salimi et al., 2013 ; Savinko et al., 2012 ; Soumelis et al., 2002 ). IL-33, TSLP, and IL-25, alone or in combination, promote type 2 cytokine production by ILC2s in vitro ( Salimi et al., 2013 ).…”