Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors

Geha, Raif S.

doi:10.1016/j.xjidi.2021.100059

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…It seems likely that some activated lung ILC2s migrate to the draining mLNs through the lymphatics and proliferate within the mLN. Increased numbers of ILC2s in other tissues draining LNs such as the skin and the gut upon inflammation have also been reported 43,44 . Role of ILC2s in the LNs is still unknown.…”

Section: Memory Ilc2s In the Lung‐draining Lymph Nodementioning

confidence: 97%

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New insights into ILC2 memory

Martinez‐Gonzalez,

Takei

2024

Immunological Reviews

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SummaryGroup 2 Innate Lymphoid Cells (ILC2s) are innate lymphocytes involved in type 2 immunity. ILC2s are abundant at the barrier tissues and upon allergen exposure, respond to epithelial‐derived alarmins by producing type 2 cytokines (e.g., IL‐5 and IL‐13). Upon activation, some of these activated ILC2s acquire immunological memory and can mount enhanced responses upon further allergen encounters. Here, we review recent findings of the cellular and molecular mechanisms underlying immune memory in ILC2s both in mice and humans and discuss the implications of memory ILC2s in the context of allergic diseases.

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Section: Memory Ilc2s In the Lung‐draining Lymph Nodementioning

confidence: 97%

“…Increased numbers of ILC2s in other tissues draining LNs such as the skin and the gut upon inflammation have also been reported. 43,44 Role of ILC2s in the LNs is still unknown. ILC2s in mLN can also become memory cells and they differ from lung memory ILC2s both at the transcriptomic and protein levels.…”

Section: Memory Ilc 2s In the Lung -Dr Aining Lymph Nodementioning

confidence: 99%

New insights into ILC2 memory

Martinez‐Gonzalez,

Takei

2024

Immunological Reviews

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“…218 Atopic dermatitis lesional skin has a defective skin barrier and a T2-dominated local immune response with an increased expression of IL-33, TSLP, and IL-25. 219 Skin inflammatory molecules, such as eosinophil peroxidase, can promote sensitization to bystander antigens, 220 and therefore lead to polysensitization.…”

Section: Rhinitis Alone and Rhinitis + Asthma Multimorbidity Represen...mentioning

confidence: 99%

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Bousquet

Melén

Haahtela

et al. 2023

Allergy

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Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper-and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper-and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

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“…До міграції в ЛВ після сенситизації гаптеном шкіри, крім ДК, залучаються також й інші імунокомпетентні клітини. Індукція запалення шкіри у сенсибілізованих оксазолоном мишей дитрансгенного типу після нанесення гаптену на поверхню шкіри посилювала міграцію циркулюючих ILC2 зі шкіри до дренажних ЛВ [9]. Субпопуляція дермальних Vg4 Т-клітин також може мігрувати до ЛВ.…”

Section: вступunclassified

“…Відомо, що навіть локально (топографічно) імунозапальний процес, який розвивається, в організмі ссавців тварин певною мірою викликає зміни стану лімфогемопоетичного комплексу [43]. Це не дивно з урахуванням наведеної вище інформації про міграцію з вогнища запалення центральних його ‚гравців‛ у вигляді дендритних та інших імунокомпетентних клітин (ІКК) у лімфогемопоетичні структури організму [8][9][10]…”

Section: результатиunclassified

Cord Blood as a Corrector of Hematological and Cytomorphological Characteristics of Lymphohemopoietic Organs in Experimental Atopic Dermatitis

Koval,

Bondarovych,

Goltsev

2023

Innov Biosyst Bioeng

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Background. Atopic dermatitis (AD) is an inflammatory skin disease caused by a shift in the interaction between cells of the immune system and the skin. Steroid anti-inflammatory drugs used to treat AD often lead to numerous side effects. Therefore, the development of new natural multifunctional preparations with immunomodulatory activity is of great importance. Objective. To determine the changes in indices of the leukocytes cluster of peripheral blood and determine the peculiarities of cytomorphological changes in the spleen and lymph nodes (LN) of rats with induced AD before and after administration of cryopreserved (cHCBL) and lyophilized (lHCBL) forms of human cord blood leukoconcentrate. Methods. The experiments were conducted using 6-month-old Wistar rats. AD was induced by topically applying a 5% alcohol-acetone solution of dinitrochlorobenzene (DNCB) to the skin of the rats' back for 21 days. Each form of the preparation (cHCBL and lHCBL) was administered intraperitoneally in a 0.5 ml dose containing 5´106 cells, one day after the final DNCB treatment. The following parameters were assessed in the blood: leukocyte count and the neutrophil-to-lymphocyte ratio (N/L index). Сytomorphological characteristics were determined in the spleen and inguinal LN. Results. In AD, specific changes in the cytomorphological characteristics of the lymphohematopoietic complex (LHС) structures, namely the spleen and LN, were observed alongside alterations in the leukocyte cluster indices. The most notable changes in the spleen included the dominance of the white pulp over the red pulp and the prevalence of follicles of stages II and III of development in the LN. Animals with AD displayed pronounced leukocytosis and an increased N/L index in their blood. The study demonstrates the positive corrective effects of cHCBL and lHCBL on the morphological characteristics of LHC and the specified blood parameters. Conclusions. The effectiveness of the cHCBL and lHCBL use for correcting indices of leukocytes cluster of peripheral blood and the structural organization of lymphohemopoietic organs in the development of AD have been proven.

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Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors

Cited by 5 publications

References 18 publications

New insights into ILC2 memory

New insights into ILC2 memory

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Cord Blood as a Corrector of Hematological and Cytomorphological Characteristics of Lymphohemopoietic Organs in Experimental Atopic Dermatitis

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