Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis: remarks

Shoor, Hitesh; Pai, Keerthilatha M.

doi:10.1016/j.oooo.2013.11.501

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…After screening the titles and abstracts, 97 studies were found to be irrelevant, and were thus excluded. A full-text review was conducted on the remaining 11 studies, and 6 were excluded for various reasons: two used multiple doses of doxycycline [ 12 , 15 ]; two were letters to the editor [ 22 , 23 ]; one was in-vitro study [ 14 ]; and one [ 24 ] was a conference abstract. The remaining five studies [ 4 , 13 , 17 – 19 ] fulfilled the eligibility criteria and were further processed for data extraction.…”

Section: Resultsmentioning

confidence: 99%

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

et al. 2020

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Background: Recurrent aphthous stomatitis (RAS) is a highly prevalent oral mucosal disease. The management of RAS is quite challenging, and as yet, there is no definitive cure. The present systematic review and meta-analysis assessed the efficacy of a single application of topical doxycycline for the management of RAS. Methods: A comprehensive online search of PubMed, Scopus, Embase, and Web of Science databases was conducted to identify all relevant studies published up to March 31, 2019. All randomized clinical trials that assessed the efficacy of a single application of topical doxycycline in the management of RAS were included. Primary outcome measures were pain scores and/or healing time, while secondary outcomes included the associated side effects. RevMan 5.3 software was used for data analysis. Results: Five clinical trials fulfilled the eligibility criteria, three of which were included in the meta-analysis. All of the included studies found doxycycline effective in alleviating signs and symptoms of RAS. The results of the pooled 3 studies revealed a statistically significant decrease in the healing time in favor of the doxycycline group as compared to the control groups (I 2 = 51%; MD:-1.77, 95% CI: − 2.11, − 1.42, P <0.00001); however, the results showed no significant differences between doxycycline and control groups with regard to pain reduction (I 2 = 96%; MD:-1.28, 95% CI: − 2.83, 0.27; P = 0.11). Conclusion: Although still inconclusive, the available evidence suggests that a single application of topical doxycycline might be effective for reducing signs and symptoms of RAS. However, owing to the limited number of the included studies, further well-designed clinical trials with adequate sample sizes are required to discern the clinical efficacy of topical doxycycline in patients with RAS.

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Section: Resultsmentioning

confidence: 99%

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

et al. 2020

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“…Normally, the lesions go away on their own in 7-10 days without leaving any scars. Despite the prevalence of the condition, no definite cause has been identified; thus, a number of risk factors have been proposed, including genetic predisposition, hematologic issues, immunologic defects, vitamin deficiencies, mental stress, and local trauma [4,5]. It has been demonstrated that the pathophysiology of RAS should be linked to bodily immunological issues.…”

Section: Introductionmentioning

confidence: 99%

Association of IL-1β 542 T>A gene polymorphism with recurrent aphthous stomatitis in Erbil City population

Asma Qasim Rahman,

Reiadh Kamal Al-Kamali

2024

Cell Mol Biol (Noisy-le-grand)

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Recurrent Aphthous stomatitis (RAS) is a common oral mucosal condition. The pathophysiology of RAS is affected by a variety of variables, including microbial, genetic, immunological and local and systemic diseases. Interleukin IL-1β, a cytokine that promotes inflammation, has been found in high concentrations in the circulation of RAS. The goal of the current investigation was to determine whether RAS is connected with polymorphisms of the IL-1β 542 T>A gene. A total of 60 RAS patients and 30 controls were included in the study. Biochemical investigations for determining (vitamin D, vitamin B12 and zinc) were done and genotypes of IL-1B gene polymorphisms were determined using polymerase chain reaction (PCR) and sequencing. The mean age of the participants was 30.83 ± 1.466 years (range 16 to 50). There was no significant association of SNP IL-1β 542T>A polymorphism with RAS diseases compared to controls, in both parameters such as sex (p-value=0.495) and age groups (p-value=0.6253). There was a significant difference in the occurrence of both A and T alleles between RAS patients and controls (p-value=0.0058). The mean vitamin D in both genotypes TA and TT differed significantly (p-value=0.007) but in genotype AA there was no significant difference. A significant difference was observed in zinc concentration between patients and controls (p-value=0.0031). The findings of the current investigation indicated that there is a specific IL-1β 542 T>A gene variation that is associated with the pathogenesis of RAS. Allele A was related to the risk of RAS in the Erbil City population.

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Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis: remarks

Cited by 2 publications

References 3 publications

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

Association of IL-1β 542 T>A gene polymorphism with recurrent aphthous stomatitis in Erbil City population

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