2011
DOI: 10.1590/s0100-40422011000500022
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Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration

Abstract: Recebido em 12/3/10; aceito em 17/11/10; publicado na web em 25/2/11The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose c… Show more

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Cited by 8 publications
(6 citation statements)
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References 18 publications
(20 reference statements)
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“…1 Lamivudine; 2',3'-dideoxy-3'-thiacytidine, commonly called 3TC. Spectrophotometric (6)(7)(8)(9), chromatographic [10][11][12][13][14][15][16] and electrochemistry (17)(18) analytical methods have been developed for the determination of lamivudine. As a result of advancements in properties of the adsorptive stripping voltammetry, new methodologies have been developed for adenine, thymine, guanine, ATP, DNA and antiretroviral drugs determinations, employing alkaline solution with lower ionic strength as the supporting electrolyte (19)(20)(21)(22)(23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…1 Lamivudine; 2',3'-dideoxy-3'-thiacytidine, commonly called 3TC. Spectrophotometric (6)(7)(8)(9), chromatographic [10][11][12][13][14][15][16] and electrochemistry (17)(18) analytical methods have been developed for the determination of lamivudine. As a result of advancements in properties of the adsorptive stripping voltammetry, new methodologies have been developed for adenine, thymine, guanine, ATP, DNA and antiretroviral drugs determinations, employing alkaline solution with lower ionic strength as the supporting electrolyte (19)(20)(21)(22)(23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%
“…Fig 9. Illustration of lamivudine determination in a synthetic sample contain several antiretroviral drugs (efavirenz, nevirapine, didanosine, lamivudine, zidovudine and acyclovir; all with 2 ppm of concentration) by linear cyclic adsorptive stripping voltammetry.…”
mentioning
confidence: 99%
“…As far as we know, however, there is no report in the literature about the determination of AZT and 3TC in tablets using NIR and multivariate calibration. A method for simultaneous determination of AZT and 3TC using UV-Vis spectrophotometry and multivariate calibration was developed by Grangeiro, Jr. et al [12], which were also validated according to Specific Brazilian Resolution RE no. 899 based on the ICH and IUPAC guides [27,30].…”
Section: Pls Modelsmentioning
confidence: 99%
“…In the scientific literature, some works can be found describing the use of HPLC and UVVis spectroscopy for the quantification of these drugs in pharmaceutical formulations [5][6][7][8][9][10][11][12]. These methods, however, are expensive, laborious, consume a considerable amount of reagent, and require many analytical manipulations.…”
Section: Introductionmentioning
confidence: 99%
“…A review of the literature shows that various conventional analytical methods including spectrophotometry, [1][2][3][4][5] HPTLC, 4) HPLC, [4][5][6][7][8][9][10][11][12][13] HPLC-MS 14) and multivariate calibration method 15) were reported for the analysis of LAM and ZID or their combination with other drugs in tablets, human serum and in drug dissolution studies. However, there is no continuous wavelet transform (CWT) method reported for the simultaneous quantitative estimation of both drugs.…”
mentioning
confidence: 99%