A process analytical technology approach for the production of fixed-dose combination tablets of zidovudine and lamivudine using near infrared spectroscopy and chemical images

Grangeiro, Severino; França, Leandro de Moura; Pimentel, Maria Fernanda; Albuquerque, Manoel Bandeira de; Santana, Davi Pereira de; Santana, Aíla Karla Mota; Souza, Julia Aparecida Lourenço de; Simões, Simone da Silva

doi:10.1016/j.microc.2014.07.009

Cited by 8 publications

(1 citation statement)

References 30 publications

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“…Junior et al 9 used NIR and performed a comparison between two multivariate calibration techniques, PLSR and multiple linear regression (MLR) to monitor the quality control of tablets, and the PLSR model present better results than MLR. Raman spectral imaging technique was also used to predict active ingredient pharmaceutical concentration in microtablets 10 , in oral suspensions 11 , intravaginal rings 12 , and in quantitative assessment of pharmaceutical tablets 13 .…”

Section: Medical and Pharmaceutical Applicationsmentioning

confidence: 99%

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

et al. 2019

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A compilation of papers published between 2014 and 2018 was evaluated. Many papers related to multivariate calibration and classification have been reported, as well as, design of experiments applications and artificial intelligence methods. Some applications were highlighted, as medical and pharmaceutical, food analysis, fuels, biological and forensic for the chemometric techniques on this review. Most studies are related to developing methods for practical solutions in industry or routine analysis. A promising scenario is shown considering the number of published papers: a total of 832 for this period using the keywords, multivariate classification, multivariate calibration, analysis, chemometrics, prediction, analytical chemistry, artificial neural networks (ANN), design of experiments (DoE) and factorial design. An useful overview for Analytical Chemistry researchers´ combined with Chemometrics is presented in this review.

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