Simultaneous quantitative determination of paracetamol and tramadol in tablet formulation using UV spectrophotometry and chemometric methods

Glavanović, Siniša; Glavanović, Marija; Tomišić, Vladislav

doi:10.1016/j.saa.2015.12.020

Cited by 95 publications

(45 citation statements)

References 43 publications

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“…Acetaminophen was chosen as a model drug for this study due to its high solubility in ethanol 58 and its characteristic UV− vis absorption. 59 This drug was effectively immobilized onto the PVA−MNP fibers ( Figure 4A), following which the drug−fiber system was transferred to an absolute ethanol medium and studied for the release of acetaminophen with time, both with and without magnetic actuation ( Figure 4B,C and Supporting Information Videos S2 and S3). Separate experiments were conducted in duplicate, for the control (i.e., without actuation) and actuated studies.…”

Section: Resultsmentioning

confidence: 99%

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera

Zhang

Homer‐Vanniasinkam

et al. 2018

ACS Appl. Mater. Interfaces

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An efficient method is reported, for the fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol, incorporated with citric acid-coated Fe 3 O 4 magnetic nanoparticles (MNPs), are subject to infusion gyration to generate 100− 300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks. Using acetaminophen as an example, we demonstrate that this material is effective in immobilization and triggered release of drugs, which is achieved by a moving external magnetic field. The remote actuation ability, coupled with biocompatibility and lightweight property, renders enormous potential for these fibers to be used as a smart drug release agent.

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Section: Resultsmentioning

confidence: 99%

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera

Zhang

Homer‐Vanniasinkam

et al. 2018

ACS Appl. Mater. Interfaces

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“…Therefore, its determination in biological samples such as blood, urine, and serum are great importance because the results of analyses provide information about long-term abuse and can also be used for forensic purposes 2-6 . To date, a number of studies have been performed including high performance liquid chromatography 7,8 , spectrophotometry 9 , electrochemiluminescence 10 , gas chromatography 11 and electrochemical methods [12][13][14] for quantitative analysis of TRH from drugs, biological fluids, environmental water samples. Electrochemical methods, one of these methods, provide not only benefits such as speed, precision, selectivity and cost compliance for chemical analysis, but also provide useful information about the oxido-reduction mechanism of the corresponding electroactive species.…”

Section: Introductionmentioning

confidence: 99%

Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

Keskin

Allahverdiyeva

Şeyho

et al. 2020

JSCS

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The present work describes the electroanalytical investigation and a novel voltammetric method for a cheap, fast and simple quantification of tramadol (TRH) using a boron-doped diamond (BDD) electrode. TRH displayed one well-defined, irreversible and adsorption-controlled oxidation peak at about +1.58 V (vs. Ag/AgCl) in Britton-Robinson buffer (BR, 0.1 mol L -1 , pH 3.0) using cyclic voltammetry (CV) technique. The voltammetric responses of the oxidation peaks are dependent on pH and its sensitivity was significantly enhanced in the existence of surfactant media (sodium dodecyl sulphate, SDS). In optimized experiment conditions, employing square-wave stripping mode, it was found that there was an excellent correlation between oxidation peak current and TRH concentration in the range of 0.25 to 50.0 μg mL -1 (8.34×10 -7 --1.67×10 -4 mol L -1 ), with a detection limit of 0.072 μg mL -1 (2.40×10 -7 mol L -1 ) in 0.1 mol L -1 BR buffer (pH 3.0) solution comprising 8×10 -4 mol L -1 SDS at +1.52 V (after 30 s accumulation at open-circuit condition). The developed approach can be used for the quantification of TRH in the pharmaceutical formulations and the spiked human urine samples with acceptable recoveries.

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“…Up till now, a number of studies have been performed including high performance liquid chromatography with UV and electrospray ionization mass spectrophotometric detections, gas chromatography with mass spectrophotometric detection , capillary electrophoresis , UV spectrophotometry , and voltammetry for the determination of ACP and TRA in their binary mixtures.…”

Section: Introductionmentioning

confidence: 99%

“…Up till now, a number of studies have been performed including high performance liquid chromatography with UV [7] and electrospray ionization mass spectrophotometric [8] detections, gas chromatography with mass spectrophotometric detection [7], capillary electrophoresis [9], UV spectrophotometry [10,11], and voltammetry [ 18] for the determination of ACP and TRA in their binary mixtures. Among the instrumental techniques, voltammetry provides not only inexpensive, rapid and simple benefits for chemical analysis, but also presents useful information about the oxidation/reduction (redox) mechanism of the corresponding electroactive species.…”

Section: Introductionmentioning

confidence: 99%

A Simple Approach to Simultaneous Electroanalytical Quantification of Acetaminophen and Tramadol Using a Boron‐doped Diamond Electrode in the Existence of Sodium Dodecyl Sulfate

et al. 2019

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The present work describes the individual, selective and simultaneous quantification of acetaminophen (ACP) and tramadol hydrochloride (TRA) using a modification‐free boron‐doped diamond (BDD) electrode. Cyclic voltammetric measurements revealed that the profile of the binary mixtures of ACP and TRA were manifested by two irreversible oxidation peaks at about +1.04 V (for ACP) and +1.61 V (for TRA) in Britton‐Robinson (BR) buffer pH 3.0. TRA oxidation peak was significantly improved in the presence of anionic surfactant, sodium dodecyl sulfate (SDS), while ACP signal did not change. By employing square‐wave stripping mode in BR buffer pH 3.0 containing 8×10−4 mol L−1 SDS after 30 s accumulation under open‐circuit voltage, the BDD electrode could be used for quantification of ACP and TRA simultaneously in the ranges 1.0–70 μg mL−1 (6.6×10−6–4.6×10−4 mol L−1) and 1.0–70 μg mL−1 (3.3×10−6–2.3×10−4 mol L−1), with detection limits of 0.11 μg mL−1 (7.3×10−7 mol L−1) and 0.13 μg mL−1 (4.3×10−7 mol L−1), respectively. The practical applicability of the proposed approach was tested for the individual and simultaneous quantification of ACP and/or TRA in the pharmaceutical dosage forms.

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Simultaneous quantitative determination of paracetamol and tramadol in tablet formulation using UV spectrophotometry and chemometric methods

Cited by 95 publications

References 43 publications

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

A Simple Approach to Simultaneous Electroanalytical Quantification of Acetaminophen and Tramadol Using a Boron‐doped Diamond Electrode in the Existence of Sodium Dodecyl Sulfate

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