Simultaneous Quantification of Neomycin and Bacitracin by LC-ELSD

Aerosol-based detectors for liquid chromatography

“…Scheidl et al used HPLC-ELSD for the separation and quantification of neomycin and bacitracin in sterile pharmaceutical formulations for content uniformity in quality control [36]. The Shimadzu LTII ELSD resulted in second order regression linearity of 0.9999 (neomycin) and 0.9996 (bacitracin) and accuracy values of 99.2% and 99.7% for neomycin and 100.8% for bacitracin.…”