Aerosol-based detectors for liquid chromatography

Magnusson, Lars-Erik; Risley, Donald S.; Koropchak, John A.

doi:10.1016/j.chroma.2015.07.045

Cited by 78 publications

(30 citation statements)

References 104 publications

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“…25 UV detection is generally applicable, since most compounds contain chromophores, and MS analysis is helpful for the identification of new compounds and unknown byproducts. 26 For compounds without chromophores, fast GC analysis or HPLC-CAD 27 can be used. Rapid determinations of enantiomeric excess are enabled by fast SFC analysis with chiral columns.…”

Section: Executing and Analyzing Large Arrays Of Experimentsmentioning

confidence: 99%

Practical High-Throughput Experimentation for Chemists

Shevlin

2017

ACS Med. Chem. Lett.

284

220

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Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified.

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Section: Executing and Analyzing Large Arrays Of Experimentsmentioning

confidence: 99%

Practical High-Throughput Experimentation for Chemists

Shevlin

2017

ACS Med. Chem. Lett.

284

220

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“…Charged aerosol detectors work similarly to evaporative light scattering detectors in that the column effluent is carried and aerosolized by a flow of nitrogen into a nebulizing chamber, where the low velocity large droplets are removed [45][46][47][48][49]. The remaining wide-range of droplet sizes are further dried into particles from single to hundreds of nanometers in size by passing through a drying tube.…”

Section: Standard Calibration Curve Fit and Analytical Rangementioning

confidence: 99%

Direct determination of amino acids by hydrophilic interaction liquid chromatography with charged aerosol detection

Socia

Foley

2016

Journal of Chromatography A

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“…The volatility of the mobile phase have an effect on the detector response of compound due to the improvement of droplet formation within the nebulizer spray chambers system and of mobile phase evaporation in the drying tube [19]. In this study, 5%-20% of acetonitrile in the eluent were examined, because more than 20% of acetonitrile have a bad influence on the column robustness, as suggested by Tosoh Corporation.…”

Section: Effect Of Acetonitrile Addition To a Water Eluent On The Detmentioning

confidence: 99%

The Simultaneous Determination of Silicic, Boric and Carbonic Acids in Natural Water via Ion-Exclusion Chromatography with a Charged Aerosol Detector

et al. 2016

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Abstract:The simple and simultaneous determination of silicic, boric and carbonic acids was made using ion-exclusion chromatography (IEC) and a Corona™ charged aerosol detector (C-CAD). Silicic and boric acids were separated by the column packed with a weakly acidic cation-exchange resin in H + -form and ultra-pure water eluent, and the detector responses were improved by the addition of acetonitrile to eluent. Under the optimized conditions, the simultaneous determination of weak inorganic acids, except for carbonic acid, was successfully performed. When the conversion column packed with a strong acidic cation-exchange resin in Na + -or K + -form was inserted between the separation column and the detector, weak inorganic acids including carbonic acid could be detected by the C-CAD. The calibration curves were linear in the range of 0.5-10 mg¨L´1 as Si for silicic acid (r 2 = 0.996), 10-100 mg¨L´1 as B for boric acid (r 2 = 0.998) and 1.3-21 mg¨L´1 as C for carbonic acid (r 2 = 0.993). The detection limits based on three times the standard deviation were 0.03 mg¨L´1 as Si for silicic acid, 0.40 mg¨L´1 as B for boric acid and 0.08 mg¨L´1 as C for carbonic acid. This method was applicable to river, hot spring and drinking water.

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Aerosol-based detectors for liquid chromatography

Cited by 78 publications

References 104 publications

Practical High-Throughput Experimentation for Chemists

Practical High-Throughput Experimentation for Chemists

Direct determination of amino acids by hydrophilic interaction liquid chromatography with charged aerosol detection

The Simultaneous Determination of Silicic, Boric and Carbonic Acids in Natural Water via Ion-Exclusion Chromatography with a Charged Aerosol Detector

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