Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF–MS/MS

Bhatt, Vinod; Sharma, Sushila; Kumar, Neeraj; Sharma, Upendra; Singh, Bikram

doi:10.1016/j.jpba.2016.09.035

Cited by 75 publications

(28 citation statements)

References 23 publications

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“…Polyphenols represent a wide group of plant secondary metabolites, which possess numerous biological activities including antioxidant, antimicrobial, antispasmodic, antiinflammatory, antiallergic, hepatoprotective and anticarcinogenic properties (Ben El Hadj Ali et al, 2014;Bhatt et al, 2017;Munin and Edwards-Levy, 2011;Sen and Chakraborty, 2011). Therefore, there is a growing interest for isolation of these phytochemicals from plant materials, with the aim to produce a safe, natural and low-cost alternative to synthetic compounds (Ben El Hadj Ali et al, 2014;Canadanović-Brunet et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Polyphenols extraction from plant sources

Jovanović¹,

Petrović²,

Ðordjevic³

et al. 2017

Lek sirovine

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Different conventional (maceration and heat-assisted extraction) and new alternative techniques (ultrasound-assisted and microwave-assisted extractions) have been developed for the extraction of polyphenols compounds from different plant sources. Novel procedures have established with the aim to reduce the extraction time and solvent consumption, as well as to increase polyphenols yield and to improve extract quality. A critical review was conducted to introduce and compare traditional and modern procedures applied for extraction of bioactive polyphenols compounds. This review focuses on the different techniques of polyphenols extraction, discussing their operating conditions, mechanism, choice of particle size and solvent, solid/solvent ratio, extraction time, advantages/disadvantages and effectiveness. Finally, potential application of these extraction procedures in polyphenols isolation is reviewed.

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Section: Introductionmentioning

confidence: 99%

Polyphenols extraction from plant sources

Jovanović¹,

Petrović²,

Ðordjevic³

et al. 2017

Lek sirovine

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“…The quantitative analysis was carried out on UHPLC system (BEH C18 column, 2.1 mm x 100 mm, 1.7 μm particle size) as reported in our previous paper [15]. The mobile phase consisted of water (0.05% formic acid) as solvent A and acetonitrile as solvent B, with a linear gradient at flow rate of 0.280 mL/min: 0.0-0.5 min, 90-80% A; 0.5-4.5 min, 80-48% A; 4.5-5.0 min, 48-45% A; 5.0-8.0 min, 45-30% A; F I G U R E 2 ESI-MS 2 spectra and fragmentation patterns of (A) magnoflorine (14), (B) armatamide (4), (C) kobusin (5), (D) isovitexin (19), (18) and (F) hydroxy-α-sanshool (12) 8.0-9.0 min, 30-20% A; 9.0-9.5 min, 20-90% A, 9.5-11.0 min, 90% A.…”

Section: Uhplc Condition For Quantitative Analysismentioning

confidence: 99%

Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography

Bhatt

Kumar

Sharma

et al. 2018

Separation Science Plus

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Zanthoxylum armatum and Z. acanthopodium belong to the Rutaceae family, are extensively used in traditional folk medicine and possess anti‐inflammatory, antibacterial, hepatoprotecive and antidiabetic properties. However, the comprehensive phytochemical studies of these species in order to explain medicinal properties are still not clear. In the present study, a new ultra high performance liquid chromatography method has been developed for the determination of the biologically important compounds in the different parts (leaves, bark, flowers and fruits) of Z. armatum and Z. acanthopodium. The results revealed that lignans and flavonoids are the principal components in leaves samples while aporphine alkaloids, lignans and amides are the major constituents in bark samples of Z. armatum. None of the analyzed compounds were detected in bark and leaves of Z. acanthopodium except catechin. In contrast, the fruit pericarp was characterized by the sanshool analogues, especially hydroxy‐α‐sanshool. In addition, the method was also applied for identification of 27 metabolites in the different parts of Z. armatum and Z. acanthopodium using ultra high performance liquid chromatography with tandem mass spectrometry. The identification of eight compounds in Z. armatum and metabolic profiling of Z. acanthopodium is reported here for the first time. The results obtained were also analyzed by principal component analysis to discriminate the similarity and differences among the samples.

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“…There are also several studies reported that hesperidin has beneficial antioxidant and neuroprotective effects. [12][13][14] Magnoflorine has cytotoxic and antiviral activities. 15 Melicopine is acridone alkaloids with cytotoxic and antimalarial activities.…”

Section: Identification Of Phenolic Compounds From Z Alatummentioning

confidence: 99%

“…Structure of Armatamide.A new lignan from Zanthoxylum armatumGuo et al,24 isolated a new lignan glycoside, (7S,8R)guaiacylglycerol-ferulic acid, ether-7-O-β-D-glucopyranoside, along with five known phenylpropanoids and seven phenylpropanoid glycosides(7)(8)(9)(10)(11)(12)(13), from the stems of Zanthoxylum armatum DC.…”

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confidence: 99%

A review on effective utilization, phytochemical compounds, pharmacological intervention of a popularly used plant for developing a new drug: Zanthoxylum armatum with reference to its anticancer activity

Barua

Yasmin

Elancheran

2018

MOJBB

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Traditionally it is used by the Bhotiya communities for food, medicines and exchange in the Uttaranchal, Himalaya of India. The Zanthoxylum armatum fruit is used by the Bhotiyas of Pithoragarh district of Kumaon region while those of the Kamoli district of Garhwal have developed the collection and trade of Z. armatum sticks to pilgrims visiting the shrines of Badrinath, Kedarnath, Gangotri and Yamunotri. 2 The fruits, bark and leaves are used as spice, in the Indian medicine system. Definition Zanthoxylum armatum known as winged prickly ash is a species of plant in the Rutaceae family. It is an aromatic deciduous, spiny shrub growing to 3.5 meters in height, endemic to China, Japan, Korea and India. Zanthoxylum armatum is a wild plant and mostly used as a condiment and medicine and have other medicinal properties.

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Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF–MS/MS

Cited by 75 publications

References 23 publications

Polyphenols extraction from plant sources

Polyphenols extraction from plant sources

Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography

A review on effective utilization, phytochemical compounds, pharmacological intervention of a popularly used plant for developing a new drug: Zanthoxylum armatum with reference to its anticancer activity

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