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Stannous chloride catalyzed chemoselective reductive amination of a variety of carbonyl compounds with aromatic amines has been developed for the synthesis of a diverse range of tertiary amines using inexpensive polymethylhydrosiloxane as reducing agent in methanol. The present method is also applicable for the synthesis of secondary amines including heterocyclic ones.

Herein, copper iodide nanoparticles (NPs) are reported for the reductive amination of carbonyl compounds for the first time.

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Thef irst iron(III) chloride-catalyzed decarboxylative-deaminative functionalization of phenylglycinew ith o-substituted nitroarenes was achieved for the synthesiso f4 (3H)-quinazolinones and benzimidazoles. Ther eaction of 2-nitrobenzonitrile/2nitro-N,N-diphenylamine with phenylglycine at 120 8 8Ci nt he presence of potassiumc arbonate as ab asei nt oluene generatedt he productsi n4 5-87% yields.V ariousf unctional groups like nitro,f luoride, chloride and trifluoromethyl were wellt olerated under the present reactionc onditions.I nt his tandem approach, involvement of transfer hydrogenation of the nitro functionality with in situ generated ammonia, imination, nitrileh ydration to amide and oxidative cyclization sequencesh ave been established. The process avoids the use of an externalh ydrogen source,c ostly catalysts as well as the isolation of amine and amide intermediates.

Zanthoxylum armatum and Z. acanthopodium belong to the Rutaceae family, are extensively used in traditional folk medicine and possess anti‐inflammatory, antibacterial, hepatoprotecive and antidiabetic properties. However, the comprehensive phytochemical studies of these species in order to explain medicinal properties are still not clear. In the present study, a new ultra high performance liquid chromatography method has been developed for the determination of the biologically important compounds in the different parts (leaves, bark, flowers and fruits) of Z. armatum and Z. acanthopodium. The results revealed that lignans and flavonoids are the principal components in leaves samples while aporphine alkaloids, lignans and amides are the major constituents in bark samples of Z. armatum. None of the analyzed compounds were detected in bark and leaves of Z. acanthopodium except catechin. In contrast, the fruit pericarp was characterized by the sanshool analogues, especially hydroxy‐α‐sanshool. In addition, the method was also applied for identification of 27 metabolites in the different parts of Z. armatum and Z. acanthopodium using ultra high performance liquid chromatography with tandem mass spectrometry. The identification of eight compounds in Z. armatum and metabolic profiling of Z. acanthopodium is reported here for the first time. The results obtained were also analyzed by principal component analysis to discriminate the similarity and differences among the samples.