Simultaneous occurrence of cerebellar medulloblastoma and pituitary adenoma: A case report

Samaras, Vassilis; Samaras, Efstathios; Stergiou, Ioanna Ε.; Konstantopoulou, Paraskevi; Arnaoutoglou, Christos; Arnaoutoglou, Marianthi; Varsos, Vassilis; Barbatis, Calypso

doi:10.1186/1757-1626-1-175

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Such invasive growth also causes difficulty in complete surgical resection of tumors, as well as post-operative recurrence and worse prognosis. Some studies show that the occurrence of pituitary adenoma might be related with oncogene expression or inactivation of tumor suppressor genes, although the detailed mechanism is still unclear [ 5 – 7 ]. MicroRNA (miR) is a biological marker for human malignant tumors, and exerts critical roles in biological processes in cancer.…”

Section: Introductionmentioning

confidence: 99%

Effect of miR-106b on Invasiveness of Pituitary Adenoma via PTEN-PI3K/AKT

et al. 2017

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BackgroundPituitary adenomas are mostly benign tumors, although certain cases have invasiveness, which might be related with high expression of miR-106b. The PTEN-PI3K/AKT signal pathway is known to be related with cell migration and invasion. Among these, PTEN is the target gene for miR-106b. Whether miR-106b affects invasiveness of pituitary adenoma via PTEN-PI3K/AKT is unclear.Material/MethodsBoth invasive and non-invasive pituitary adenoma tissue samples were collected from our Neurosurgery Department, in parallel with brain tissues after head contusion surgery. Pituitary adenoma cell line HP75 was cultured in vitro and divided into NC and miR-106b inhibitor groups for measuring cell cycle/proliferation. Malignant growth of cells was measured by agarose gel clonal assay, while cell migration and invasion were reflected by starch assay and Transwell assay, respectively. The expression of PTEN, PI3K/AKT, and MMP-9 was measured.ResultsMiR-106b was significantly up-regulated in pituitary adenoma but PTEN was down-regulated, especially in invasive tumors. The inhibition of miR-106b remarkably suppressed proliferation and anchorage-independent growth of HP75 cells, with major arrest of cell cycles. The inhibition of miR-106b significantly depressed starch healing and invasive potency of cells. A negative targeted regulation existed between miR-106b and PTEN, as the inhibition of miR-106b significantly enhanced PTEN expression, affecting the activity of downstream PI3K/AKT signaling pathway, thus affecting migration and invasion of pituitary adenoma.ConclusionsMiR-106b can affect migration and invasion of pituitary adenoma cells via regulating PTEN and further activity of the PI3K/AKT signaling pathway and MMP-9 expression.

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Section: Introductionmentioning

confidence: 99%

Effect of miR-106b on Invasiveness of Pituitary Adenoma via PTEN-PI3K/AKT

et al. 2017

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“…[1,2] Pituitary adenomas (PA) are reported to co-occur with various grades of glial neoplasms, gliomatosis cerebri, schwannomas, medulloblastomas, and meningiomas. [1][2][3][4][5][6][7] The coexisting pituitary tumor varied from clinically silent lesions to functioning adenomas like prolactinomas and growth hormone (GH)-and thyrotropin (TSH)-secreting tumors. [1,2,[4][5][6]8] We evaluated the possible tumor induction factors and previously described genetic abnormalities which could link the two unrelated pathologies.…”

Section: Introductionmentioning

confidence: 99%

Coexisting intracranial tumors with pituitary adenomas: Genetic association or coincidence?

et al. 2010

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The co-occurrence of two or more brain tumors with different histological features is rare. The authors report three rare cases of intracranial tumors associated with pituitary adenomas. Two of the pituitary tumors were functioning adenomas: a prolactinoma and a thyrotropin secreting adenoma. Two of the associated intracranial neoplasms were gliomas and one was a meningioma. Radiological and clinical examination for syndromal association was negative in all cases. We briefly discuss the presentation and treatment options of these cases and review the 19 previous publications in the literature of pituitary tumors occurring in association with other neoplasms and explore the possible links underlying these co-occurring neoplasms. Our three cases represent 0.86% of all pituitary tumors operated at our institute over a 9-year period.

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“…We have previously used the UPDB to show patterns of such clustering, which have been observed among some, but not all cancers; pituitary cancer was not analyzed. 18 There have been few studies noting the association of other tumors in patients harboring pituitary tumors 1,2,6,8,9,12,13,16 (recently reviewed by Furtado et al 10 ). These reports are supported by data from the current study, which indicate that there is a significantly elevated co-prevalence of other tumors in patients harboring pituitary tumors in the UPDB and their relatives.…”

Section: Co-prevalence Of Other Tumorsmentioning

confidence: 99%