Coexisting intracranial tumors with pituitary adenomas: Genetic association or coincidence?

Furtado, Sunil V.; Venkatesh, Prasanna K.; Ghosal, Nandita; Hegde, Alangar S.

doi:10.4103/0973-1482.65246

Cited by 29 publications

(40 citation statements)

References 12 publications

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“…Furthermore, in neurofibroma (type 2), a mutation in NF2, a tumor suppressor gene located at chromosome position 22q12, has been associated with the formation of various intracranial tumors, including meningiomas, gliomas and vestibular schwannomas (16). In addition, Furtado et al (11,15) reported three cases of pituitary adenoma associated with two cases of glioma and one case of meningioma, and demonstrated that these tumors resulted from gene mutations common to both tumor types in each case. However, various gene mutations have been identified in pituitary adenomas and other intracranial tumors, such as gliomas and meningiomas, that have different roles in each tumor type.…”

Section: Discussionmentioning

confidence: 99%

“…Amit et al (6) and Furtado et al (11) have previously speculated that different intracranial tumors may originate from cellular remnants left following embryogenesis. This hypothesis appears to be supported by a case of craniopharyngioma associated with pituitary adenoma and notochordoma reported by Shishkina et al (31).…”

Section: Discussionmentioning

confidence: 99%

“…However, numerous reports have described incidences of pituitary adenoma concomitant with other types of cranial cavity tumor, such as meningioma (2)(3)(4), medulloblastoma (5), neurinoma (6), craniopharyngioma (7), astrocytoma (8) and glioma (9). While the etiology and underlying mechanisms for the development of these tumors remain unclear, it has been proposed that genomic and endocrine disorders, as well as radiation therapy and embryogenesis, may be important factors (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The majority of pituitary adenomas concomitant with other cranial tumors are diagnosed by MRI or CT, current treatment strategies include the simultaneous or staged resection (12).…”

Section: Introductionmentioning

confidence: 99%

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Prolactinoma associated with an ependymoma in the fourth ventricle: A case report and review of the literature

Yang

et al. 2015

Oncology Letters

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Abstract. Pituitary adenoma associated with ependymoma in the fourth ventricle is a rare condition. In the present study, a 46-year-old man diagnosed with prolactinoma, who previously underwent two surgical procedures (one for the removal of a primary tumor and a second following its recurrence) developed a complication of ependymoma in the fourth ventricle. The presence of the ependymoma was confirmed by pathological analysis and the patient recovered well following two-phase surgical resection of the two tumors. The present study compared the probable cause of concurrent pituitary adenoma and ependymoma within the fourth ventricle with previous relevant studies. These comparisons were used to propose possible genomic and endocrine contributions for the development of the ependymoma from the pituitary adenoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prolactinoma associated with an ependymoma in the fourth ventricle: A case report and review of the literature

Yang

et al. 2015

Oncology Letters

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“…The coexistence of PA and another type of brain tumor is a very rare clinical scenario (4,5). The type of PAs reported in such series varied from, clinically silent lesions "non-functional" to functioning adenomas such as prolactinomas and growth hormone (GH)-and thyrotropin (TSH)-secreting tumors (1,4,(6)(7)(8)(9). In cases of PA concurrent with meningioma, GH-secreting adenoma is the most predominant (9)(10)(11).…”

Section: Background and Importancementioning

confidence: 99%

“…Concomitant brain tumor and association of PA with other tumors comprise 15−25% of all intracranial neoplasms with an annual incidence of 6/100,000 (1). Pituitary adenomas (PAs) are very common benign neoplasms, with a prevalence of 10 to 23% in unselected adult population considering population surveys, radiological, and autopsy series (2,3).…”

Section: Background and Importancementioning

confidence: 99%

Coexisting Pituitary Adenoma and Suprasellar Meningioma: A Coincidence or Causation Effect? Report of Two Cases and Review of Literature

Mortazavi¹,

Shirani²,

Saeedinia³

et al. 2015

IrJNS

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Background and Importance:The coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. Even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated. Case Presentation: Two cases of concomitant sellar and suprasellar region tumors are reported. A 37-year-old lady with Prolactinoma and a suprasellar meningioma and a 42-year-old Acromegalic man with suprasellar meningioma and a pituitary adenoma (PA). Conclusion Both meningiomas were removed transcranially while the Prolactinoma could be managed medically and the growth hormone (GH) secreting adenoma was removed trans-sphenoidally. The visual problems and hormonal imbalances of both patients improved postoperatively and there has been no sign of recurrence of the lesions after a mean of five years follow up. The literature is reviewed on this topic and the possible pathogenesis and management protocol of similar lesions are discussed.

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Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor

et al. 2012

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Familial isolated pituitary adenoma (FIPA), defined as the occurrence of at least two cases of pituitary adenoma in a family that does not exhibit features of syndromic diseases, such as Carney complex or Multiple Endocrine Neoplasia type 1 or 4, is a rare autosomal dominant disease with low penetrance. About 20 % of the families with FIPA harbor inactivating mutation in aryl hydrocarbon receptor-interacting protein gene (AIP) associated with loss of heterozygosity of the same genetic locus (11q13) in the tumor. Rarely different types of extra-pituitary tumors have been described in the setting of AIP mutation-positive FIPA. We present the case of a patient who was diagnosed with acromegaly due to the AIP mutation c.241C>T (p.R81X) at the age of 34 years, and treated by transsphenoidal surgery. At the age of 43 years she was diagnosed with a meningioma, and at age 46 had recurrence of the somatotropinoma. Genetic studies demonstrated loss of the normal allele (by sequencing and microsatellite analysis) in DNA from the pituitary adenoma but not from the meningioma, suggesting a selective involvement of AIP mutation in the pathogenesis of the pituitary adenoma, and a casual association with the meningioma. Further investigations are required to define the exact role of AIP in non-pituitary tumorigenesis.

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Coexisting intracranial tumors with pituitary adenomas: Genetic association or coincidence?

Cited by 29 publications

References 12 publications

Prolactinoma associated with an ependymoma in the fourth ventricle: A case report and review of the literature

Prolactinoma associated with an ependymoma in the fourth ventricle: A case report and review of the literature

Coexisting Pituitary Adenoma and Suprasellar Meningioma: A Coincidence or Causation Effect? Report of Two Cases and Review of Literature

Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor

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