Simultaneous Measurements of the Blood Volume in Man and Dog by Means of Evans Blue Dye, T1824, and by Means of Carbon Monoxide. Ii. Under Abnormal Conditions, Including Secondary Shock 1

Hopper, James; Winkler, Alexander W.; Elkinton, J. R.

doi:10.1172/jci101534

Cited by 20 publications

(11 citation statements)

References 31 publications

(26 reference statements)

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“…A more variable relationship was found in abnormal subjects. Dye volumes were considerably higher than CO volumes in dogs in experimental traumatic shock, the discrepancy tending to increase as the hematocrit rose with hemoconcentration (14).…”

mentioning

confidence: 77%

The Measurement of the Circulating Red Cell Volume by Means of Two Radioactive Isotopes of Iron 1

Gibson¹,

Weiss²,

Evans³

et al. 1946

J. Clin. Invest.

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Measurement of blood volume, both of its plasma and red cell portion, is a useful tool in clinical and experimental investigation. It provides basic data for the assay of the total quantity of individual blood components, as well as for the evaluation of observed hemodynamic changes in acute or chronic disturbances of the circulation. Blood volume determinations have proved of value in the study of congestive heart failure, the anemias, thyroid disorders, renal disease, and pregnancy; and they have been particularly useful-during the recent war years in the study of hemorrhage, burns and shock, and in the development of blood substitutes and blood cell preservatives.It seems reasonable to state that the dye method (1, 2) measures the circulating plasma volume with a high degree of accuracy both in normal and pathologic states, and in many clinical and experimentally induced abnormal circulatory conditions. This view appears to be shared by investigators who have had firsthand experience with the technique (3, 4).Perhaps the best experimental evidence that the method accurately measures changes in plasma volume was obtained in a series of experiments in which the increase in plasma volume following the intravenous injection of concentrated (25 per cent) human serum albumin was measured (5).The osmotic equivalent of 1 gram of this protein was found by Scatchard et al (6) to be 18 ml. of H20; the average increase in plasma volume in 11 male human subjects was 17.4 ml. of H20 (5) per gram of albumin.

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confidence: 77%

The Measurement of the Circulating Red Cell Volume by Means of Two Radioactive Isotopes of Iron 1

Gibson¹,

Weiss²,

Evans³

et al. 1946

J. Clin. Invest.

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“…The range of ratios in individual cases was from 0.91 to 1.16 in man, and from 0.72 to 1.14 in the dogs, and in each series the number of cases with ratios less than unity was about equal to those with ratios greater than unity. They found the ratios to be even more variable in abnormal subjects (20).…”

mentioning

confidence: 99%

Circulating Red Cell Volume Measured Simultaneously by the Radioactive Iron and Dye Methods 1

Gibson¹,

Peacock²,

Seligman³

et al. 1946

J. Clin. Invest.

132

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“…The third variable, relative red blood cell volume, was measured by means of the hematocrit. Only results obtained in normal subjects are included in this paper; those in pathological subjects are presented in the following paper (3). Such simultaneous or nearly simultaneous measurements have only rarely been made (4 to 10), and very seldom with satisfactory modern technics.…”

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confidence: 99%

Simultaneous Measurements of the Blood Volume in Man and Dog by Means of Evans Blue Dye, T1824, and by Means of Carbon Monoxide. I. Normal Subjects 1

Hopper¹,

Tabor²,

Winkler³

1944

J. Clin. Invest.

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Simultaneous Measurements of the Blood Volume in Man and Dog by Means of Evans Blue Dye, T1824, and by Means of Carbon Monoxide. Ii. Under Abnormal Conditions, Including Secondary Shock 1

Cited by 20 publications

References 31 publications

The Measurement of the Circulating Red Cell Volume by Means of Two Radioactive Isotopes of Iron 1

The Measurement of the Circulating Red Cell Volume by Means of Two Radioactive Isotopes of Iron 1

Circulating Red Cell Volume Measured Simultaneously by the Radioactive Iron and Dye Methods 1

Simultaneous Measurements of the Blood Volume in Man and Dog by Means of Evans Blue Dye, T1824, and by Means of Carbon Monoxide. I. Normal Subjects 1

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