Simultaneous kinetic–spectrophotometric determination of mycophenolate mofetil and mycophenolic acid based on complexation with Fe(III) using chemometric techniques

Bahram, Morteza; Mojarrad, Sima; Moghtader, Mehdi

doi:10.1007/s13738-017-1276-9

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…The reaction order was then established corresponding to the donor reactant (TIGC) in the presence of a fixed concentration of acceptor (TCNQ). In this study, several kinetic models were used, including the initial rate, rate constant, fixed concentration, and fixed time approaches [ 50 , 51 , 52 , 53 , 54 ]. Moreover, these techniques were evaluated, and the choice of the best technique depended merely on the relevance, LOD, LOQ, and linear range of the acquired data.…”

Section: Resultsmentioning

confidence: 99%

Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

2022

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Tigecycline (TIGC) reacts with 7,7,8,8-tetracyanoquinodimethane (TCNQ) to form a bright green charge transfer complex (CTC). The spectrum of the CTC showed multiple charge transfer bands with a major peak at 843 nm. The Plackett–Burman design (PBD) was used to investigate the process variables with the objective being set to obtaining the maximum absorbance and thus sensitivity. Four variables, three of which were numerical (temperature—Temp; reagent volume—RV; reaction time—RT) and one non-numerical (diluting solvent—DS), were studied. The maximum absorbance was achieved using a factorial blend of Temp: 25 °C, RV: 0.50 mL, RT: 60 min, and acetonitrile (ACN) as a DS. The molecular composition that was investigated using Job’s method showed a 1:1 CTC. The method’s validation was performed following the International Conference of Harmonization (ICH) guidelines. The linearity was achieved over a range of 0.5–10 µg mL−1 with the limits of detection (LOD) and quantification (LOQ) of 166 and 504 ng mL−1, respectively. The method was applicable to TIGC per se and in formulations without interferences from common additives. The application of the Benesi–Hildebrand equation revealed the formation of a stable complex with a standard Gibbs free energy change (∆G°) value of −26.42 to −27.95 kJ/mol. A study of the reaction kinetics revealed that the CTC formation could be best described using a pseudo-first-order reaction.

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Section: Resultsmentioning

confidence: 99%

Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

2022

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“…[36][37][38][39] Actually, such advantages would resolve additive interferences that have a probable influence on other procedures, such as the volumetric titration and direct spectrophotometric techniques. [40][41][42] Additionally, all interferences caused by tinted or further ingredients in the pharmaceutical formulations could be avoided to the extent that they do not contribute to the reactions introduced for developing the kinetic technique. 43,44 Thus, this study was performed for designing an easy, fast, highly sensitive, strongly selective and affordable kinetic spectrophotometric procedure for quantification of cisplatin in the human serum and urine during the chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

A New Sensitive Method for Quantitative Determination of Cisplatin in Biological Samples by Kinetic Spectrophotometry

2020

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This study describes a kinetic spectrophotometric method for accurate, sensitive and rapid determination of cisplatin in biofluids. The developed method is based on the inhibitory effect of cisplatin on the oxidization of Janus Green by bromate in acidic media. The change in absorbance as the criteria of the oxidation reaction was followed spectrophotometrically. To obtain the highest rate of sensitivity, efficient reaction parameters were optimized. Under optimum experimental conditions, a calibration graph was obtained linearly over the range 10.0 -5750.0 μg L -1 and the limit of detection (3sb/m) was 4.2 μg L -1 of cisplatin. The interfering effect of diverse species was investigated. The developed method was used for the quantification of cisplatin in bio fluids of patients treated with cisplatin, spiked bio fluids and pharmaceutical samples and yielded satisfactory results.

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Facile fabrication of a novel disposable pencil graphite electrode for simultaneous determination of promising immunosuppressant drugs mycophenolate mofetil and tacrolimus in human biological fluids

et al. 2019

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Simultaneous kinetic–spectrophotometric determination of mycophenolate mofetil and mycophenolic acid based on complexation with Fe(III) using chemometric techniques

Cited by 6 publications

References 38 publications

Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

A New Sensitive Method for Quantitative Determination of Cisplatin in Biological Samples by Kinetic Spectrophotometry

Facile fabrication of a novel disposable pencil graphite electrode for simultaneous determination of promising immunosuppressant drugs mycophenolate mofetil and tacrolimus in human biological fluids

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