2014
DOI: 10.3358/shokueishi.55.34
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Simultaneous Identification of 18 Illegal Adulterants in Dietary Supplements by Using High-Performance Liquid Chromatography-Mass Spectrometry

Abstract: We developed a method for the identification of 18 illegal adulterants in dietary supplements for erectile dysfunction by using high-performance liquid chromatography-mass spectrometry. The separation was achieved on a Cosmosil 3C 18 -EB column. The mobile phase consisted of 0.1 formic acid solution and 0.1 formic acid in acetonitrile, with gradient elution at a flow rate of 0.15 mL/ min. The proposed method may be useful for the identification of illegal adulterants and for quality control of dietary suppleme… Show more

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Cited by 5 publications
(2 citation statements)
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References 8 publications
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“…The literature declares that many analytical approaches were reported for simultaneous quantification of PDE-5 inhibitors SLD, TAD, and VAR in counterfeit drugs, pharmaceutical products and dietary supplements using different analytical techniques including TLC and HPLC-PDA-MS methods, 13 HPLC-UV-ESI-MS, 9 LC-MS, 26 LC-MS/MS, 27–29 LC/HRMS, 30 HPLC-DAD and LC-MS/MS. 10 SLD, TAD and YHB was analyzed by pulsed amperometric detection using a gold electrode coupled to HPLC separation.…”
Section: Introductionmentioning
confidence: 99%
“…The literature declares that many analytical approaches were reported for simultaneous quantification of PDE-5 inhibitors SLD, TAD, and VAR in counterfeit drugs, pharmaceutical products and dietary supplements using different analytical techniques including TLC and HPLC-PDA-MS methods, 13 HPLC-UV-ESI-MS, 9 LC-MS, 26 LC-MS/MS, 27–29 LC/HRMS, 30 HPLC-DAD and LC-MS/MS. 10 SLD, TAD and YHB was analyzed by pulsed amperometric detection using a gold electrode coupled to HPLC separation.…”
Section: Introductionmentioning
confidence: 99%
“…45,46,47,48,49,50,51 Adulterants are even found in dietary supplements for erectile dysfunction. 19,52 Look for third-party confirmation of the ingredients list from a trusted source. Often, labels are intentionally confusing.…”
mentioning
confidence: 99%