Lodenafil

Alshehri, Yahya M; Al-Majed, Abdulhakeem A.; Attwa, Mohamed W.; Bakheit, Ahmed H.

doi:10.1016/bs.podrm.2021.10.004

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Several phosphodiesterase type 5 (PDE-5) inhibitors, including sildenafil, tadalafil, vardenafil, avanafil, udenafil, mirodenail, and lodenafil carbonate, have gained approval as therapeutic agents for patients with erectile dysfunction in numerous countries [ [1] , [2] , [3] , [4] ]. It is crucial to underscore that these drugs should only be administered under medical supervision due to their potential adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Isolation and identification of a novel vardenafil analogue, propoxy-vardenafil, found as an adulterant in a health supplement

Sun

Zhang

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Isolation and identification of a novel vardenafil analogue, propoxy-vardenafil, found as an adulterant in a health supplement

Sun

Zhang

et al. 2023

Heliyon

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“…Lodenafil carbonate (LC), a drug developed in Brazil, it is used to treat erectile dysfunction and consists of a dimer formed by two lodenafil molecules connected by a carbonate bridge (Figure 1) (Alshehri et al, 2022;Scaglione et al, 2017;Davis et al, 2012;Codervilla et al, 2013). After ingestion, the carbonate bridge is broken, releasing two molecules of lodenafil.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic study of lodenafil carbonate electrochemical reduction in acid medium

Carvalho,

Galli,

Machado

et al. 2023

OLEL

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The electrochemical reduction mechanism of lodenafil carbonate in acidic medium was studied using cyclic voltammetry, square wave voltammetry and chronoamperometry (sulfuric acid 0.1 mol L-1, potential controlled at -1.2 V). The formed product characterization was carried out by FT-IR spectroscopy combined with quantum calculations of the lodenafil molecular orbitals. Over the products IR spectrum, it was possible to note the presence of absorption bands corresponding to the aldehyde, amine and ethanol groups. These results, together with those obtained by electrochemical techniques and quantum calculations, allowed us to propose that the process of reducing lodenafil is dependent on protons and occurs in four irreversible steps, the first being the amide group reduction to an aldehyde and a primary amine. Then, the aldehyde is reduced to an alcohol, with the consumption of two electrons and two protons in each of these steps. Then, there is a reduction in two processes of one electron and one proton each, one of which by a radical way. In this last process, there are two possibilities: one is the sulfone group reduction and the other is the azomethine reduction adjacent to the amine group formed in the previous step.

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Sexual Disorders and Sexual Dysfunction

Shafer

2025

Massachusetts General Hospital Comprehensive Clinical Psychiatry

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Lodenafil

Cited by 4 publications

References 33 publications

Isolation and identification of a novel vardenafil analogue, propoxy-vardenafil, found as an adulterant in a health supplement

Isolation and identification of a novel vardenafil analogue, propoxy-vardenafil, found as an adulterant in a health supplement

Mechanistic study of lodenafil carbonate electrochemical reduction in acid medium

Sexual Disorders and Sexual Dysfunction

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