Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC

Stability studies on some benzocycloheptane antihistaminic agents

“…Methods have been described in the literature for the determination of loratadine whether alone or in combination with other drugs or in presence of its metabolites. The methods cited in the literature for the determination of loratadine as raw material or in dosage form (single or combined) included HPLC [3][4][5][6][7][8][9], capillary electrophoresis [10] spectrophotometric [5][6][7][11][12][13][14], polarographic [15,16] and densitometric method [7,17]. Methods used for the determination of loratadine in human plasma included HPLC [18][19][20] and a gas liquid chromatographic method [21].…”

“…Methods used for the determination of loratadine in human plasma included HPLC [18][19][20] and a gas liquid chromatographic method [21]. The HPLC methods [3][4][5][6] reported for the determination of loratadine in dosage forms were not specified as stability indicating. Methods [7][8][9][10] were stability-indicating HPLC and capillary electrophoresis procedures reported for the determination of loratadine in presence of alkaline degradation products [7] or loratadine related impurities [8][9][10].…”

Differential Pulse Voltammetric and Conductimetric Determination of Diphenylpyraline HCl in Raw Material and Pharmaceutical Preparation

“…Few number of methods have been adopted for the determination of Di-HCl including its determination in human plasma with other ten antihistamine drugs using pipette tip solid-phase extraction, gas chromatography and mass spectrometry [1], in syrup using HPLC [2,3], in raw material and pharmaceutical preparation using spectrophotometric method via the formation of mixed aggregates with surfactants [4]. No electroanalytical methods have been published for the determination of the investigated drug.…”

HPLC determination of phenylpropanolamine in pharmaceutical OTC preparations

“…Several methods have been reported for the determination of PPA in different dosage forms including tablets (Das Gupta and Heble, 1984;Ferreyra and Ortiz, 2001;Swanepoel et al, 1996;Rind et al, 2001), hard capsules (Swanepoel et al, 1996) and syrup (Swanepoel et al, 1996;Vasudevan et al, 2001). In these methods, the separation of PPA and other studied ingredients was achieved by reversed-phase HPLC with UV detection (Das Gupta and Heble, 1984;Ferreyra and Ortiz, 2001), UV-diode array detector (Vasudevan et al, 2001) and with fluorescence detection after precolumn derivatization with o-pthalaldehyde (Swanepoel et al, 1996) or 4-dimethylaminobenzaldehyde (Rind et al, 2001).…”

“…In these methods, the separation of PPA and other studied ingredients was achieved by reversed-phase HPLC with UV detection (Das Gupta and Heble, 1984;Ferreyra and Ortiz, 2001), UV-diode array detector (Vasudevan et al, 2001) and with fluorescence detection after precolumn derivatization with o-pthalaldehyde (Swanepoel et al, 1996) or 4-dimethylaminobenzaldehyde (Rind et al, 2001). Other reported methods determined PPA in pharmaceutical preparations by normal phase HPLC (Taylor et al, 1984) or without separation using Raman spectrometry (King et al, 1985).…”