New Chlorphenoxamine (Ch) ion selective plastic membrane electrodes for both conventional and coated wire types based on the ion associate of Ch-HCl with sodium tetraphenylborate (NaTPB) and phosphotungestic acid (PTA) were prepared. The conventional type electrode was fully characterized in terms of membrane composition, plasticizer, filling solution, life span, pH, ionic strength, temperature. The membranes of optimum compositions were used for the preparation of both graphite and cupper coated wire electrodes. The prepared electrodes were used for the potentiometric determination of the investigated drug in raw material and pharmaceutical preparations under batch and flow injection analysis conditions. The selectivity of the electrodes towards a large number of excipients like inorganic cations, sugars, amino acids and other antihistaminic drugs was tested. Determination of Ch-HCl, the solubility product of the ion associate and the formation constant of the precipitation reaction leading to the ion associate formation of Ch-HCl with NaTPB and PTA were carried out using conductimetric measurements.
Voltammetric methods have been used for the determination of chlorphenoxamine hydrochloride (Ch-HCl) in raw material and in its pharmaceutical preparations (Allergex and Allergex caffeine tablet). It was found that Ch-HCl gives a characteristic cyclic voltammetric (CV) and differential pulse voltammetric (DPV) peak in acetonitrile using platinum and glassy carbon working electrodes. The I p of the DPV peak increases linearly within the concentration range from 4.5 9 10 -4 to 1.0 9 10 -2 mol L -1 of the investigated drug. The concentration of Ch-HCl in raw drug material and in its pharmaceutical preparations was determined using the standard addition method, RandlesSevcik equation and indirectly via its complexation with sodium tetraphenylborate (NaTPB). The obtained over all average recoveries were 101.44 and 100.49% with SD 0.45 and 0.38 (n = 4) for platinum and glassy carbon electrodes, respectively. The effect of scan rate, sample concentration, and supporting electrolyte on the I p and E p was also investigated.
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