Simultaneous electrochemical sensing of warfarin and maycophenolic acid in biological samples

Gholivand, Mohammad Bagher; Solgi, Mohammad

doi:10.1016/j.aca.2018.06.045

Cited by 10 publications

(3 citation statements)

References 50 publications

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“…These analysis results of CV behaviors show that the dominant peak at m / z = 338.16 is produced by the catalysis of the phenolic hydroxyl group of the MPA molecule. The catalytic oxidation of the phenolic hydroxyl group in MPA involves a two-electron oxidation process, followed by a nucleophilic attack of water molecules at the para position of the hydroxyl group. − Accordingly, it can be concluded that an equal number of electrons and protons are involved in the electro-oxidation of MPA molecules on the surface of the 2D Cu–TCPP-modified electrode. According to these results, the catalytic oxidation mechanism of MPA is suggested in Scheme .…”

Section: Resultsmentioning

confidence: 99%

Ultrathin Cu–TCPP Nanosheet-Based Electrochemical Microsensor for Detecting the Immunosuppressive Drug Mycophenolic Acid

Deng,

Jin,

Yang

et al. 2023

ACS Appl. Nano Mater.

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Section: Resultsmentioning

confidence: 99%

Ultrathin Cu–TCPP Nanosheet-Based Electrochemical Microsensor for Detecting the Immunosuppressive Drug Mycophenolic Acid

Deng,

Jin,

Yang

et al. 2023

ACS Appl. Nano Mater.

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“…It should be noted that the stripping analyses have the lowest limits of detection of any of the commonly used electroanalytical techniques. Gholivand et al 70 developed a ASV method for simultaneous determination of warfarin and mycophenolic acid by using CPE modified with b-cyclodextrin/multi-walled carbon nanotubes/cobalt oxide nanoparticles (b-CD/MWCNTs/Co 3 O 4 NPs/CPE) as working electrode. LOD of reported method for warfarin and mycophenolic acid in serum and urine samples were 0.02 and 0.03 µmol L -1 , respectively.…”

Section: Resonance Light Scattering Methodsmentioning

confidence: 99%

A Comprehensive Review on Developed Pharmaceutical Analysis Methods by Iranian Analysts in 2018

2020

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This article summarizes the publishing activities including bioanalytical and pharmaceutical analyses researches carried out in Iran in 2018 in order to connect academic researchers to those in industry, medical care units and hospitals. A wide spectrum of analytical methods has been used to determine and/or evaluate drug levels in the biological samples, based on physical, chemical and biochemical principles. We have compiled a concise survey of the literature covering 125 reports and tabulated the relevant analytical parameters. Chromatographic and electrochemical methods were found to be the technique of choice for many workers and almost 83% studies were performed by using these methods. This is the first annual review of the literature searching in SCOPUS database for published bioanalytical and pharmaceutical analysis researches in Iran.

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“…TDM requires determining drug concentrations in a biological matrix at certain times relative to administration. Various methods have been proposed for warfarin determination, such as High performance Liquid Chromatography coupled with ultraviolet (UV) [5][6][7] and fluorescence [8] detectors, fluorimetry [9], ultra-performance liquid chromatography tandem mass spectrometry [10], supercritical fluid chromatography-tandem mass spectrometry [11], capillary electrophoresis-mass spectrometry [12] and electrochemistry [13,14].…”

Section: Introductionmentioning

confidence: 99%

Detection and quantification of warfarin in pharmaceutical dosage form and in spiked human plasma using surface enhanced Raman scattering

Sultan

El‐Alamin

Wark

et al. 2020

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Analytical approaches for the quantitation of warfarin in plasma are high in demand. In this study, a novel surface enhanced Raman scattering (SERS) technique for the quantification of the widely used anticoagulant warfarin sodium in pharmaceutical dosage form and in spiked human plasma was developed. The colloidal-based SERS measurements were carefully optimised considering the laser wavelength, the type of metal nanoparticles, their surface functionalization and concentration as well as the time required for warfarin to associate with the metal surface. Poly(diallyldimethylammonium chloride) coated silver nanoparticles (PDDA-AgNPs) were established as a substrate which greatly enhanced the weak warfarin Raman signal with high reproducibility. The limit of detection was calculated in both water and human plasma to be 0.56 nM (0.17 ngmL -1 ) and 0.25 nM (0.08 ngmL -1 ) respectively, with a high degree of accuracy and reproducibility. The proposed method is simple, economical, and easily applied for routine application requiring only small plasma samples and also could be potentially useful for pharmacokinetic research on warfarin.

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Simultaneous electrochemical sensing of warfarin and maycophenolic acid in biological samples

Cited by 10 publications

References 50 publications

Ultrathin Cu–TCPP Nanosheet-Based Electrochemical Microsensor for Detecting the Immunosuppressive Drug Mycophenolic Acid

Ultrathin Cu–TCPP Nanosheet-Based Electrochemical Microsensor for Detecting the Immunosuppressive Drug Mycophenolic Acid

A Comprehensive Review on Developed Pharmaceutical Analysis Methods by Iranian Analysts in 2018

Detection and quantification of warfarin in pharmaceutical dosage form and in spiked human plasma using surface enhanced Raman scattering

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