Abolghasem (2019) A single-shot diagnostic platform based on copper nanoclusters coated with cetyl trimethylammonium bromide for determination of carbamazepine in exhaled breath condensate. Microchimica Acta, 186 (3). 194 1-8.ABSTRACT 31 A fluorescent nanoprobe is designed for the determination of carbamazepine (CBZ) in exhaled 32 breath condensate (EBC) of patients receiving CBZ. The probe consists of copper nanoclusters 33 (Cu NCs) coated with cetyl trimethylammonium bromide. The interaction of probe with CBZ 34 results in blocking non-radiative e -/h + recombination defect sites on the surface of Cu NCs and 35 consequently enhancing the fluorescence intensity of Cu NCs. The experimental conditions were 36 optimized by using a response surface methodology (central composite design). Under the 37 optimized conditions, the calibration plot is linear in the 0.2 to 20 µg mL -1 CBZ concentration 38 range (excitation/emission wavelength: 290/480 nm) and the detection limit is as low as 0.08 µg 39 mL -1 . The intra-day and inter-day relative standard deviations for six replicated measurements of 40 10 µg mL -1 CBZ are 3.9 % and 4.8 %, respectively. The method was applied for the 41 determination of CBZ level in EBC of patients receiving CBZ. The accuracy of the method was 42 confirmed by HPLC-UV analysis as a references method. 43 44 45 surface methodology; central composite design; 47 48 3 49 1. Introduction 50 Carbamazepine (5H-dibenzo [b,f] azepine-5-carboxamide, CBZ) is a carboxamide 51 derivative of iminostilbene [1] and widely used for the therapy of patients with partial and 52 generalized tonic-clonic epilepsy and psychiatric diseases [2]. So far, various methods, such as 53 liquid chromatography-electrospray ionization mass spectrometry method (LC-EIA-MS) in 54 serum samples [3], LC-MS-MS method in whole blood, serum and plasma [4], ion mobility 55 spectrometry in formulation samples [5], stacking capillary electrophoresis method in serum 56 samples [6], high-performance liquid chromatography-diode array detection assay after a simple 57 sample preparation method by a packed sorbent in plasma samples [7], online solid phase 58 extraction -LC coupled with high resolution mass spectrum under targeted MS/MS analysis 59 mode in serum sample [8], and a gas chromatography method [9] have been developed for the 60 determination of CBZ. Although the advantages of such methods are undeniable, most of these 61 techniques need a sample preparation procedure to remove matrix components or a derivatization 62 step before analysis and also a labelled internal standard. So, development of an easy-to-use 63 method that can be applied for off-and on-line determination of drugs concentrations in 64 biological samples has always been of interest in bioanalytical and clinical applications. It is 65 important to note that the assay of biomolecules should be fast, cost-effective, selective, and 66 sensitive. For this purpose, increasing attention has been focused on the construction of 67 fluorescent nanoprobes for drugs [10]. Qua...
An important factor affecting the model accuracy is the unit expression type for solute and solvent concentrations. One can report the solute and solvent concentration in various units and compare them with various error scales. In order to investigate the unit and error scale expression effects on the accuracy of the Jouyban–Acree model, in the current study, seventy-nine solubility data sets were collected randomly from the published articles and solute and solvent concentrations in the investigated systems were expressed in various units. Mass fraction, mole fraction, and volume fraction were the employed concentration units for the solvent compositions, and mole fraction, molar, and gram/liter were the investigated concentration units for the solutes. The solubility data, with various solute/solvent concentration units, were correlated using the Jouyban–Acree model, and the accuracy of each model for correlating the data was investigated by calculating different error scales and discussed.
Aim: Two approaches based on molecularly imprinted polymers-stir bar sorptive extraction (MIP-SBSE) and -magnetic solid-phase extraction (MIP-MSPE) have been used for extraction of carbamazepine (CBZ) from serum samples. Methodology: In MSPE and SBSE, development was achieved by employing a polycaprolactam coating. The Cecil® chromatographic system equipped with a UV-Vis detector was used for analytical determination of CBZ. Results: The linearity of calibration curves was in the concentration ranges of 0.2–12 and 0.05–12 μg ml-1 for MIP-SBSE and MIP-MSPE, respectively. Conclusion: MIP-MSPE was selected in preference to MIP-SBSE since lower limits of detection were achievable using MIP-MSPE method. The CBZ-MIP-MSPE-HPLC-UV method was successfully applied to CBZ determination in real serum samples of patients receiving CBZ.
This article summarizes the publishing activities including bioanalytical and pharmaceutical analyses researches carried out in Iran in 2018 in order to connect academic researchers to those in industry, medical care units and hospitals. A wide spectrum of analytical methods has been used to determine and/or evaluate drug levels in the biological samples, based on physical, chemical and biochemical principles. We have compiled a concise survey of the literature covering 125 reports and tabulated the relevant analytical parameters. Chromatographic and electrochemical methods were found to be the technique of choice for many workers and almost 83% studies were performed by using these methods. This is the first annual review of the literature searching in SCOPUS database for published bioanalytical and pharmaceutical analysis researches in Iran.
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