Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant

Semreen, Mohammad H.; Shanableh, Abdallah; Semerjian, Lucy; Alniss, Hasan; Mousa, Mouath; Bai, Xue; Acharya, Kumud

doi:10.3390/molecules24030633

Cited by 37 publications

(15 citation statements)

References 58 publications

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“…As clearly shown in Figure 5 , recoveries of seven target compounds ranged from 63% (PARA) to 110% (CARBA). The low recovery of PARA was also mentioned in previous studies [ 38 , 39 ].…”

Section: Resultssupporting

confidence: 74%

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater

Bui

Phung-Thi

et al. 2021

Journal of Analytical Methods in Chemistry

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In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. The method includes enrichment and clean-up steps by solid phase extraction using mix-mode cation exchange, followed by identification and quantification using an ultrahigh-performance liquid chromatography and tandem mass spectrometry and employing electrospray ionization (UPLC-ESI-MS/MS). Seven target compounds were separated on the reversed phase column and detected in multiple reaction monitoring (MRM) mode within 6 minutes. The present study also optimized the operating parameters of the mass spectrometer to achieve the highest analytical signals for all target compounds. All characteristic parameters of the analytical method were investigated, including linearity range, limit of detection, limit of quantification, precision, and accuracy. The important parameter in UPLC-ESI-MS/MS, matrix effect, was assessed and implemented via preextraction and postextraction spiking experiments. The overall recoveries of all target compounds were in the ranges from 55% to 109% and 56 % to 115% for surface water and hospital wastewater, respectively. Detection limits for surface water and hospital wastewater were 0.005–0.015 µg L−1 and 0.014–0.123 µg L−1, respectively. The sensitivity of the developed method was allowed for determination of target compounds at trace level in environmental water samples. The in-house validation of the developed method was performed by spiking experiment in both the surface water and hospital wastewater matrix. The method was then applied to analyze several surface water and hospital wastewater samples taken from West Lake and some hospitals in Vietnam, where the level of these pharmaceutical product residues was still missed. Sulfamethoxazole was present at a high detection frequency in both surface water (33% of analyzed samples) and hospital wastewater (81% of analyzed samples) samples.

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“…As clearly shown in Figure 5 , recoveries of seven target compounds ranged from 63% (PARA) to 110% (CARBA). The low recovery of PARA was also mentioned in previous studies [ 38 , 39 ].…”

Section: Resultssupporting

confidence: 74%

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater

Bui

Phung-Thi

et al. 2021

Journal of Analytical Methods in Chemistry

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“…In connection with the above, an important task for analysts is to monitor the concentrations of residues of biologically active compounds in surface waters and wastewater. Among the medicines often found in water and wastewater samples are: antibiotics, analgesics, beta-blockers, anti-inflammatory, and antidepressants [1].…”

Section: Introductionmentioning

confidence: 99%

Determination of Budesonide and Sulfasalazine in Water and Wastewater Samples Using DLLME-SFO-HPLC-UV Method

Hryniewicka

Starczewska

Gołębiewska

2019

Water

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Dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFO) was applied to isolate budesonide (BUD) and sulfasalazine (SULF) from aqueous samples. The effects of different parameters on the efficiency on the extraction such as type of extrahent and dispersive solvent, ionic strength, pH of sample, and centrifugation time were investigated. Moreover, the influence of foreign substances on a studied process was tested. The calibration curves were recorded. The linearity ranges for BUD and SULF were 0.022-8.611 µg mL −1 and 0.020-7.968 µg mL −1 with the limit of detection (LOD) 0.011 µg mL −1 and 0.012 µg mL −1 , respectively. The enrichment factors (EF) for two analytes were high: for BUD it was 145.7 and for SULF, 119.5. The elaborated procedure was applied for HPLC-UV determination of these analytes in water and wastewater samples.was quantitated in a range of different matrices using high-performance liquid chromatography with diode array detection or ultraviolet detection (HPLC-DAD and HPLC-UV) [10][11][12], thin-layer chromatography densitometry [13], nuclear magnetic resonance (NMR) [14], spectroflourimetry [15] and liquid chromatography/positive-ion electrospray ionization mass spectrometry (LC-ESI(+)-MS/MS [16]. None of the above methods attempted the simultaneous analysis of BUD and SULF in the same sample.The literature review shows that budesonide assays were made in biological samples [7-9], environmental samples [17,18], pharmaceutical formulations, and cosmetic products [19]. SULF was determined in pharmaceutical preparations [13][14][15], human plasma [10,16], water, and wastewater samples [20,21]. SULF was determined in river samples at the concentration of 15-76 ng L −1 and in wastewater samples at 65 ng L −1 (influent) and 266 ng L −1 (effluent) [20].Traditionally, the sample treatment techniques used to isolate pharmaceuticals from water samples have been the liquid-liquid extraction (LLE) and the solid-phase extraction (SPE) [21]. LLE technique needs large volumes of toxic solvent, and the creation of emulsions is a common problem. However, SPE technique requires column conditioning and a process that is sometimes complicated and time-consuming. Therefore, the development of environmentally friendly pretreatment methods is necessary to overcome such disadvantages. Currently, microextraction techniques are often used to separate biologically active substances from aqueous solutions.A novel dispersive liquid-liquid microextraction based on the solidification of floating organic drop (DLLME-SFO) was introduced by Leong et al. [22]. It involves the use of extraction solvent with a density lower than the density of water and freezing point near to the room temperature. The mixture of the dispersing and extracting solvent is injected into the water sample to form a turbid solution. After centrifugation, the tube is placed in an ice bath to solidify the extractant. The solidified drop is then collected and placed in a conical tube and allowed to melt. The li...

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“…Semreen ve diğ. [52] tarafından yapılan çalışmada, "Biyolojik Arıtma+Hızlı Kum Filtrasyonu+UV Dezenfeksiyon Sistemi" içeren Birleşik Arap Emirlikleri Sharjah Atıksu Arıtma Tesisi giriş ve çıkış suyunda 10 farklı farmasotik için elde edilen giderim verimleri %31-96 arasında değişmektedir. Tesiste arıtma sonrası en yüksek giderimin asetaminofen, en düşük giderimin ise eritromisin için elde edildiği belirtilmektedir.…”

Section: Sulama Suyu Geri̇ Kazaniminda Aritma Seçenekleri̇unclassified

Aritilmiş Kentsel Atiksularin Sulamada Kullaniminda Mi̇kroki̇rleti̇ci̇leri̇n Oluşturabi̇leceği̇ Ri̇skler

Yaşar¹,

Doğan²

2020

Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi

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Teknolojinin hızlı gelişimi ile birlikte kentsel, tarımsal, endüstriyel ve rekreasyonel su ihtiyacının artış gösterdiği son dönemde arıtılmış kentsel atıksuların sulama amaçlı kullanımı büyük bir potansiyel su kaynağı olarak görülmektedir. Ancak özellikle ikincil arıtılmış atıksularda yeterli düzeyde giderilemeyen mikrokirleticilerin varlığı yeni bir endişe kaynağıdır. Bu tür atıksuların ileri arıtım teknikleri ile üçüncül arıtım yapıldıktan sonra sulamada kullanımı halk ve çevre sağlığı tehditlerini gidermek için zaruri bir ihtiyaçtır. Bu konuda arıtılmış atıksulardaki mikrokirleticilerden kaynaklanan çevresel riskler göz önüne alınmamaktadır. Ayrıca bu kirleticilerle ilgili deşarj standartlarının kabulündeki karmaşalar, atıksuların yeniden kullanımı/geri kazanımı önündeki engeller arasında yer almaktadır. Bu çalışma, kentsel arıtılmış atıksuların sulamada kullanımında endişe yaratan mikrokirleticiler, bu kirleticilerle ilgili yasal yönergeler, mikrokirleticilerin çevrede yaratacağı riskler ile bunların su ortamından uzaklaştırılması için uygulanan arıtma seçenekleri üzerine odaklanmıştır. Bu kapsamdaki literatür çalışmaları, mikrokirleticilerin ileri arıtma proseslerinin yanı sıra yenilikçi hibrit uygulamalar ile yüksek verimlerde giderildikten sonra arıtılmış kentsel atıksuların sulamaya uygun hale getirilebileceğini vurgulamaktadır.

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Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant

Cited by 37 publications

References 58 publications

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater

Determination of Budesonide and Sulfasalazine in Water and Wastewater Samples Using DLLME-SFO-HPLC-UV Method

Aritilmiş Kentsel Atiksularin Sulamada Kullaniminda Mi̇kroki̇rleti̇ci̇leri̇n Oluşturabi̇leceği̇ Ri̇skler

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