Simultaneous determination of paracetamol and chlorpheniramine in human plasma by liquid chromatography–tandem mass spectrometry

Celma, C.; Allué, J.A; Pruñonosa, J; Peraire, Concepción; Obach, R.

doi:10.1016/s0021-9673(99)01252-2

Cited by 79 publications

(42 citation statements)

References 16 publications

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“…7 shows the chromatogram of serum sample of the subjects after a single oral administration of 6 mg of CPA. The concentration of CPA in this chromatogram corresponds to 3.5 ng/mL, and the value was similar to previous studies [20,[32][33]. On the other hand, MDCPA…”

Section: Determination Of Cpa and Mdcpa In Human Serumsupporting

confidence: 90%

“…Also, the detection limit of the proposed method was almost same as that of HPLC-MS methods [20,32,33].…”

mentioning

confidence: 74%

“…However, these methods lack the sensitivity for the determination of CPA in biological samples. Recently, highly sensitive methods using HPLC-mass spectrometry (MS) have been developed for the determination of CPA [32,33] or the simultaneous determination of both CPA and MDCPA in human plasma [20]. Although these analytical methods employing HPLC-6 MS or HPLC-MS/MS afford high sensitivity, the cost of the equipment still limits its application.…”

Section: Introductionmentioning

confidence: 99%

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Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence-labeled chlorpheniramine with Suzuki coupling reaction

et al. 2010

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Section: Determination Of Cpa and Mdcpa In Human Serumsupporting

confidence: 90%

“…Also, the detection limit of the proposed method was almost same as that of HPLC-MS methods [20,32,33].…”

mentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence-labeled chlorpheniramine with Suzuki coupling reaction

et al. 2010

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“…Gas chromatographic, HPLC, spectrophotometric, radioimmunoassay, capillary electrophoresis and CL methods have been applied to the analysis of this compound (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)]. Recently, an LC-MS-MS method, using 2-acetamidophenol as an internal standard, was reported for the determination of CPA (46). A micellar liquid chromatography and an ion-pairing RP-HPLC method were also applied to analysis of CPA (39).…”

Section: +mentioning

confidence: 99%

Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

et al. 2008

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] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 mg/ml were obtained. The detection limit was 0.04 mg/ml and the relative standard deviation (RSD) was always < 5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.

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“…Chlorpheniramine maleate, as an antihistamine, has been widely used for symptomatic relief of common colds and allergic diseases. Among the analytical techniques, high-performance liquid chromatography (HPLC) [2,3] have been used for the determination of chlorpheniramine maleate. Capillary electrophoresis-Ru(bpy) 3 2+ lectrochemiluminescence is a highly sensitive and selective detection means in analytical chemistry because of its excellent stability and high efficiency in the aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

Determination of Plasma Protein Binding by Microdialysis Coupled with Online Capillary Electrophoresis Electrochemiluminescence

Xiang¹,

Yang²,

Gao³

2015

Proceedings of the International Conference on Advances in Energy, Environment and Chemical Engineering

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Abstract. An ultrasonic microdialysis coupled with online capillary electrophoresis electrochemiluminescence method has been established for the sensitive determination of plasma protein binding. The drug and blood plasma were mixed in different molar ratios and incubated at 37 °C in 10 mmol/L phosphate buffer (pH 7.5) in a water bath. The concentration of unbound chlorpheniramine maleate was determined by CE-ECL. The conditions affecting separation and detection were investigated. Under the optimized conditions: ECL detection at 1.2V, dialysis time 1.5h, protein binding rate of chlorpheniramine maleate with human plasma protein were determinated. The human plasma protein binding rate of chlorpheniramine maleate was 72.3%.

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Simultaneous determination of paracetamol and chlorpheniramine in human plasma by liquid chromatography–tandem mass spectrometry

Cited by 79 publications

References 16 publications

Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence-labeled chlorpheniramine with Suzuki coupling reaction

Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence-labeled chlorpheniramine with Suzuki coupling reaction

Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

Determination of Plasma Protein Binding by Microdialysis Coupled with Online Capillary Electrophoresis Electrochemiluminescence

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