Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction

Shang, Dewei; Wang, Xipei; Zhao, Xiutai; Huang, Fumin; Tian, Ganzhong; Lu, Wei; Zhou, Tianyan

doi:10.1016/j.jchromb.2011.09.025

Cited by 22 publications

(12 citation statements)

References 26 publications

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“…As shown in Figure and Table , HCT was rapidly but incompletely absorbed from the gastrointestinal tract when administered alone, and the peak concentration of 377.42 ± 115.86 ng/ml occurred at 1.82 h. The MRT was 3.70 ± 1.57 h, which was similar to a previous report [18]. An obvious decrease in the peak concentration and a longer MRT of HCT were observed when CLO was co‐administered with HCT.…”

Section: Resultssupporting

confidence: 86%

Enhanced absorption and bioavailability of hydrochlorothiazide by Chinese medicines in the Zhenju antihypertensive compound

Qin

Wang

et al. 2014

Journal of Pharmacy and Pharmacology

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Section: Resultssupporting

confidence: 86%

Enhanced absorption and bioavailability of hydrochlorothiazide by Chinese medicines in the Zhenju antihypertensive compound

Qin

Wang

et al. 2014

Journal of Pharmacy and Pharmacology

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“…Zendelovska, Stafilov, and Milosevski () tested two solid‐phase extractions (C 18 and RP‐selected B) and obtained satisfactory results for the recovery of HCT and caffeine (IS) with RP‐select B cartridges. Shang et al (), however, developed an HPLC with on‐line SPE and DAD detection for the simultaneous determination of nitrendipine and HCT in rat plasma. Sample preparation by SPE to remove interfering biomatrix substances was carried out testing several SPE columns (Capcell PAK MF Ph‐1, Capcell PAK MF SCX and Capcell PAK MF C 8 columns).…”

Section: Resultsmentioning

confidence: 99%

Development and validation of a reversed‐phase high‐performance liquid chromatographic method with solid‐phase extraction for the quantification of hydrochlorothiazide in ex vivo permeation studies

Onnainty

Schenfeld

Longhi

et al. 2017

Biomedical Chromatography

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Hydrochlorothiazide (HCT) is a diuretic used to treat hypertension. In order to study its intestinal permeation behavior applying an ex vivo methodology, a rapid, sensitive and selective reversed-phase liquid chromatography (RP-HPLC) method coupled with UV detection (RP-HPLC UV) was developed for the analysis of HCT in TC199 culture medium used as mucosal and serosal solutions in the everted rat intestinal sac model. Also, analytical procedures for the quantification of HCT by RP-HPLC with UV detection required a sample preparation step by solid-phase extraction. The method was validated in the concentration range of 8.05 × 10 to 3.22 × 10 m for HCT. Chromatographic parameters, namely carry-over, lower limit of quantification (1.4491 × 10 m), limit of detection (3.8325 × 10 m), selectivity, inter- and intraday precision and extraction recovery, were determined and found to be adequate for the intended purposes. The validated method was successfully used for permeability assays across rat intestinal epithelium applying the ex vivo everted rat gut sac methodology to study the permeation behavior of HCT.

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“…Shang et al [61] described a HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 µL) were injected directly onto a CAPCELL MF C 8 SPE column.…”

Section: Hplc With On-line Solid-phase Extractionmentioning

confidence: 99%

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

Savaj¹,

Patidar²,

Raj³

2015

Int J of Adv in Sci Res

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Hydrochlorothiazide is chemically 6-chloro-1, 1-dioxo-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide. Hydrochlorothiazide is a diuretic drug used for treatment of high blood pressure (hypertension) and accumulation of fluid (edema). It works by blocking salt and fluid reabsorption from the urine in the kidneys, causing increased urine output (dieresis). Hydrochlorothiazide is used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, corticosteroid medications, and nephrotic syndrome. It can be used alone or in conjunction with other blood pressure lowering medications to treat high blood pressure.This review focuses on the recent developments in analytical techniques for estimation of Hydrochlorothiazide alone or in combinations with other drugs in various biological media like human plasma and urine. This review will critically examine the (a) sample pretreatment method such as solid phase extraction (SPE), (b) separation methods such as thin layer chromatography (TLC), high performance liquid chromatography (HPLC), ultra performance liquid chromatography (UPLC), high performance thin layer chromatography (HPTLC), liquid chromatography coupled to tandem mass spectrometry (LC-MS) and capillary electrophoresis (CE), (c) other methods such as spectrophotometry, diffuse reflectance near infrared spectroscopy and electrochemical methods.

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Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction

Cited by 22 publications

References 26 publications

Enhanced absorption and bioavailability of hydrochlorothiazide by Chinese medicines in the Zhenju antihypertensive compound

Enhanced absorption and bioavailability of hydrochlorothiazide by Chinese medicines in the Zhenju antihypertensive compound

Development and validation of a reversed‐phase high‐performance liquid chromatographic method with solid‐phase extraction for the quantification of hydrochlorothiazide in ex vivo permeation studies

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

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