Enhanced absorption and bioavailability of hydrochlorothiazide by Chinese medicines in the Zhenju antihypertensive compound

Qin, Jing; Wang, Limin; Yu, Bin; Li, Yongji; Jing, Yingchun; Han, Limei; Wang, Jianxin

doi:10.1111/jphp.12207

Cited by 6 publications

(2 citation statements)

References 21 publications

(28 reference statements)

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“…Zhenju antihypertensive tablet was independently developed by China and has been widely used in clinic since 1960 s. So far, it has accumulated a large number of clinical data [9] . Zhenju antihypertensive tablet is a compound preparation of traditional Chinese and western medicine composed of wild chrysanthemum, pearl layer powder, rutin, clonidine hydrochloride (CLO) and hydrochlorothiazide (HCT) [10] . The pearl layer powder in Zhenju antihypertensive tablet and wild chrysanthemum work together to calm the liver, clear heat, and reduce fire [11] .…”

Section: Introductionmentioning

confidence: 99%

“…[9] Zhenju antihypertensive tablet is a compound preparation of traditional Chinese and western medicine composed of wild chrysanthemum, pearl layer powder, rutin, clonidine hydrochloride (CLO) and hydrochlorothiazide (HCT). [10] The pearl layer powder in Zhenju antihypertensive tablet and wild chrysanthemum work together to calm the liver, clear heat, and reduce fire. [11] Clonidine hydrochloride can reduce blood pressure by reducing sympathetic activity, peripheral vascular resistance and heart rate.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the effects of Zhenju antihypertensive tablet on efficacy, safety and vascular endothelial function in patients with essential hypertension

et al. 2021

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Background: As a compound preparation of traditional Chinese and western medicine included in Volume 20 of Chinese traditional Medicine prescription, Zhenju antihypertensive tablet has been widely used in the treatment of patients with essential hypertension (EH) for many years. This study intends to evaluate the efficacy, safety and vascular endothelial function of Zhenju antihypertensive tablet in the treatment of essential hypertension.Methods: The search strategies of different websites were searched on Cochrane Central controlled Trials Registry, PubMed, excerpt database, Chinese Biomedical Literature Database, China National knowledge Infrastructure, Chinese Science and Technology Journal Database, WanFang, and other websites. All qualified studies were confirmed to include randomized controlled trials. The search time range was from January 1, 1900 to August 31, 2021. At the same time, the list of references and related reviews were checked. Two evaluators were responsible for the extraction and management of the data independently. The literature quality was evaluated according to Cochrane manual 4.2.2. Heterogeneity test and Meta analysis were carried out by Review ManagerV.5.3 software. The bias risk included in the study was evaluated by Cochrane "bias risk" tool. In addition, the relevant statistical data were evaluated by GRADE3.6 evidence quality grading system.Results: This study intends evaluate the efficacy and safety of Zhenju antihypertensive tablet in the treatment of EH from 4 aspects, including changes in blood pressure (systolic blood pressure, diastolic Blood pressure), effective hypotension, changes in endothelial function (NO, the level of plasma endothelin-1 in serum), and adverse reactions. Conclusion:The conclusion of this study intends to provide evidence for judging the effectiveness and safety of ZJAHC intervention on EH patients and their endothelial function.PROSPERO registration number: PROSPERO CRD42021235309.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of the effects of Zhenju antihypertensive tablet on efficacy, safety and vascular endothelial function in patients with essential hypertension

et al. 2021

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Development of an LC‐MS/MS method for determining the pharmacokinetics of clonidine following oral administration of Zhenju antihypertensive compound

Qin

Wang

et al. 2014

Biomedical Chromatography

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Zhenju antihypertensive compound (ZJAHC) is a combined Chinese-Western medicine formula including clonidine (CLO), hydrochlorothiazide (HCT), rutin, Chrysanthemum indicum extract and pearl powder. Compared with CLO preparations, ZJAHC shows improved activities and decreased adverse effects. It is believed that the side effects of CLO are caused by its high peak plasma concentration. Hence, study of the influence of ZJAHC on the pharmacokinetic behaviors of clonidine seems essential. In present study, the plasma concentrations of CLO were determined with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The MS/MS transitions monitored for clonidine and internal standard were 230.2 → 213.1 and 152.2 → 110.2, respectively. The analyte was quantified in a single run within 3 min. The pharmacokinetic study showed that the area under the plasma concentration-time curve of CLO in ZJAHC (60 µg/kg CLO) was similar to that of CLO-HCT-high (120 µg/kg CLO) but the peak concentration was much lower than that in CLO-HCT-high. ZJAHC could enhance the bioavailability without greatly increasing peak concentration of clonidine. This comprehensive effect of enhancing the bioavailability and avoiding the high peak plasma concentration for CLO might mainly result from the co-contribution of Western medicine and traditional Chinese medicine (TCM), while the effect of TCM was stronger than that of Western medicine.

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Synergistic Herb Interactions with Cardiovascular Drugs

Hemaiswarya¹,

Prabhakar²,

Doble³

2022

Herb-Drug Combinations

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Enhanced absorption and bioavailability of hydrochlorothiazide by Chinese medicines in the Zhenju antihypertensive compound

Abstract: The combination of traditional Chinese medicines and chemical drugs may provide a promising strategy and unique advantages to reduce the dosage and side effects of chemical drugs while maintaining an effect on hypertension.

Cited by 6 publications

References 21 publications

Analysis of the effects of Zhenju antihypertensive tablet on efficacy, safety and vascular endothelial function in patients with essential hypertension

Analysis of the effects of Zhenju antihypertensive tablet on efficacy, safety and vascular endothelial function in patients with essential hypertension

Development of an LC‐MS/MS method for determining the pharmacokinetics of clonidine following oral administration of Zhenju antihypertensive compound

Synergistic Herb Interactions with Cardiovascular Drugs

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