Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry

Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry

“…Tmax (h) Cmax (ng/mL) T 1/2 (h) AUC (0-t) (ng h/mL) AUC (0-∞) (ng h/mL) MRT (0-t) (h) CL/F (L/h kg) C max at 8-12 h and declined quickly, as was reported by Tong et al [20]. Evidence was provided that glucuronidation, enteric circulation and enterohepatic circulation may contribute to the biphasic pharmacokinetics [12,13,21].…”

Pharmacokinetic and Pharmacodynamic Studies of Four Major Phytochemical Components of Da-Cheng-Qi Decoction to Treat Acute Pancreatitis

“…One reason is that the in vivo dose is underestimated, given that rhein can be biotransformed from aloe-emodin (16), another DCQD component not quantitated in this study. Another reason is that although hesperidin is the most abundant compound in DCQD, it shows poor water solubility like many other flavonoids, leading to poor bioavailability (17). Magnolol showed similar behavior: although it was present with rhein at a 1.33:1 (w/w) ratio in DCQD extract, its serum concentration in rats was only 5.739 ± 1.888 g min/ml based on the AUC from t = 0 to the final time point.…”

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

“…Linearity was achieved between 100 and 10,000 nM for racemic hesperetin in urine and between 50 and 5000 nM for (S)-and (R)-hesperetin in urine. In another study, Tong et al determined naringin, hesperidin, neohesperidin, naringenin and hesperetin in rat plasma using liquiritin as the internal standard [171].…”