Simultaneous determination of hydrochlorothiazide and valsartan in combined dosage forms: Electroanalytical performance of cathodically pretreated boron-doped diamond electrode

Overview of the Determination of Hydrochlorothiazide Levels in Pharmaceutical Preparations and Biological Matrices

“…This method demonstrated a linear response to HCTZ and VAL in the concentration range of 1.97-88.1 μmol/L and 9.88-220 μmol/L, respectively, in a Britton-Robinson buffer solution (pH 5.0), with detection limits of 0.639 μmol/L and 0.935 μmol/L, respectively. The proposed method was successfully applied in the two antihypertensives' simultaneous determination in the combined dosage form, and the results were obtained using the highperformance liquid chromatography method [21].…”

Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid

“…As summarized in Table 1, both LOD and LOQ were at the level of µmol L −1 , being those achieved using SPCE/EGA lower than for SPCE/PGA. Table 2 presents a comparison of the results obtained from SPCE/PGA and SPCE/EGA and those from other electrodes used in the determination of HCTZ, e.g., glassy carbon electrode [47], boron-doped diamond electrode [18], modified graphene oxide sheet paste electrode [48], or modified carbon paste electrodes [49,50]. In comparison with the summarized results, the LOD and LOQ values reached in this work for HCTZ determination are similar or even slightly lower depending on both the electrode and method considered.…”

“…Nevertheless, these techniques have some disadvantages, such as high initial investment (equipment), the need for sample pre-treatments, time-consuming procedures, required expertise, and the high cost of consumables. In this sense, electroanalytical methods play a fundamental role and are stated as a very notable alternative for the determination of this anti-hypertensive drug [13][14][15][16][17][18]. In particular, voltammetric techniques provide excellent detection and quantification limits, high sensitivity and selectivity, with relatively low economic cost.…”

Synthesis of nickel nanowrinkles and its application for the electrocatalytic oxidation and sensitive detection of hydrochlorothiazide

“…Several methods have been proposed for the individual or simultaneous determination of hydrochlorothiazide with other pharmaceutical compounds including chemometry [7], spectroscopy [8][9][10][11], capillary electrophoresis [12,13], high performance liquid chromatography (HPLC) [14][15][16][17], time resolved chemiluminescence [18], liquid chromatography/tandem mass spectrometry [19,20], chemometry [21], and electrochemistry [22][23][24][25][26].…”