Synthesis of nickel nanowrinkles and its application for the electrocatalytic oxidation and sensitive detection of hydrochlorothiazide

Abstract

Nickel nanowrinkles were synthesized by a simple hydrothermal method in one step in the presence of fluoride ions in ethylene glycol. The nanowrinkles were then employed as the modifier of a carbon paste electrode. The kinetics of the charge transfer across the modified electrode/solution interface was studied and the modified electrode was employed to fabricate an amperometric sensor of hydrochlorothiazide. The mechanism and kinetics of the electrocatalytic oxidation of hydrochlorothiazide on the modified electrode surface were studied by cyclic voltammetry and chronoamperometry. An amperometric procedure was developed for determination of hydrochlorothiazide with a sensitivity of 13.50 mA mol-1 dm 3 cm-2 and a limit of detection of 21.2 mol dm-3. The method was used for the direct assay of hydrochlorothiazide in human serum samples and hydrochlorothiazide tablets. The sensor had the advantages of sensitivity (guaranteed by a Nafion layer on the sensor surface), high electrocatalytic activity and long-term stability toward hydrochlorothiazide.

Recent Trends in the Improvement of the Electrochemical Response of Screen-Printed Electrodes by Their Modification with Shaped Metal Nanoparticles

“…The HCT is a drug extensively used for hypertension treatment, increasing the excretion of sodium chloride and water from the kidney [ 90 ]. The HCT is also used for heart failure treatment, liver cirrhosis, and kidney disorders [ 91 ]. The authors prepared the La 3+ -doped ZnO nanoflowers using nano-powders: zinc acetate, lanthanum nitrate, and thiourea ammonia.…”

Copper/copper oxide nanoparticles synthesis usingStachys lavandulifoliaand its antibacterial activity

“…Nanomaterials show novel biological and physicochemical properties in comparison with the bulk of counterparts [1,2]. A large number of physicochemical and green approaches used to synthesise different nanostructures of carbon, noble metals, and transition metal oxides [3][4][5][6][7][8][9][10].…”

Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid

“…As summarized in Table 1, both LOD and LOQ were at the level of µmol L −1 , being those achieved using SPCE/EGA lower than for SPCE/PGA. Table 2 presents a comparison of the results obtained from SPCE/PGA and SPCE/EGA and those from other electrodes used in the determination of HCTZ, e.g., glassy carbon electrode [47], boron-doped diamond electrode [18], modified graphene oxide sheet paste electrode [48], or modified carbon paste electrodes [49,50]. In comparison with the summarized results, the LOD and LOQ values reached in this work for HCTZ determination are similar or even slightly lower depending on both the electrode and method considered.…”